ArticleNature communications2025
The bHLH transcription factor PIL1 orchestrates starch synthesis in key cereal crops.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Integrated transcriptomic and metabolomic analysis reveals candidate regulatory networks associated with starch accumulation in tetraploid potato.Functional & integrative genomics · 2026Article
- Transcriptional reprogramming of heat-sensitive maize anther development under heat stress.BMC plant biology · 2026Article
- Functional Analysis ofPlants (Basel, Switzerland) · 2026Article
- Multi-Omics Reveals Salt Stress Effects on Quality Formation of Strong-Gluten Wheat.International journal of molecular sciences · 2026Article
- Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages.International journal of molecular sciences · 2026Review
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Authors and funding
10 authors.
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Abstract
Key cereal crops, including wheat, rice and maize, supply nearly 50% of the world's caloric intake, with starch constituting over 70% of the grain weight. However, the regulatory mechanisms underlying starch synthesis are poorly understood. In this study, we identify a transcription factor TaPIL1-5D, which binds to the promoters of ADP-glucose pyrophosphorylase small subunit 1 (TaAGPS1a-7A), granule-bound starch synthase I (TaGBSSI-4A), and branching enzyme II b (TaBEIIb-2D). Similarly, its homologous OsPIL11 and ZmPIL1 also activate the expression of the AGPS1, BEIIb, and GBSSI, and positively regulates grain starch synthesis. TaPIL1-5D and ZmPIL1 improve grain yields in two successive years. Nine alleles of TaPIL1-5B form three distinct haplotypes (Hap1-3), while TaPIL1-5B-Hap1 is repressed due to its binding by the transcriptional repressor TaBZR1.1. Additionally, TaPIL1-5B interacts with TaPIL1-5D in the nucleus, enhancing its transcriptional activation. Collectively, our study enriches the starch regulatory network and provides a promising tool for improving starch content.
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