Evidence map›Paper›PMID 41372155›Full record

ArticleNature communications2025

Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes.

Ping Yuan, Guodong Chen, Yukun Li, Xichun Liu, Shayana Saravanakumar, Jianfeng Zhao, Qianyu Ji, Hong Wang, Ying-Wu Lin, Mostafa Elbahnasawy and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ping Yuan *Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Guodong Chen *Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Yukun Li *Tumor ImmunoMetabolism Institute, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China.ORCID http://orcid.org/0000-0002-8517-9075
Xichun LiuSchool of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan, China.ORCID http://orcid.org/0000-0003-2860-8205
Shayana SaravanakumarW.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-6741-5943
Jianfeng ZhaoDepartment of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Qianyu JiState Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Hong WangDepartment of Scientific Research, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Ying-Wu LinSchool of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan, China.ORCID http://orcid.org/0000-0002-2457-0871
Mostafa ElbahnasawyLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-1749-3388
Nan-Ping WengLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Brian G PierceW.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. pierce@umd.edu.ORCID http://orcid.org/0000-0003-4821-0368
Roy A MariuzzaW.M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD, USA. rmariuzz@umd.edu.ORCID http://orcid.org/0000-0003-0748-5875
Daichao WuDepartment of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. wudaichao@usc.edu.cn.ORCID http://orcid.org/0000-0003-2086-0190

Funding

High resolution modeling and design of immune recognitionR35GM144083 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI Brian G. Pierce · 2022 to 2026
$1.6M
Structural Basis for T Cell Recognition of SARS-CoV-2R21AI169181 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI MARIUZZA, ROY A, PIERCE, BRIAN G. · 2023 to 2024
$426k
NIAID NIH HHS R21 AI169181NIGMS NIH HHS R35 GM144083U.S. Department of Health & Human Services | National Institutes of Health (NIH) AI169181
6 · The paper itself

Abstract

T cells play a crucial role in clearing SARS-CoV-2 and in forming long-term memory responses to that coronavirus. The highly immunogenic nucleocapsid (N) protein of SARS-CoV-2 is much more conserved than the spike (S) protein across variants of concern, making it an attractive vaccine target for activating cytotoxic CD8

Indexed as

Coronavirus Nucleocapsid ProteinsEpitopes, T-LymphocyteImmunodominant EpitopesSARS-CoV-2CD8-Positive T-LymphocytesCOVID-19Crystallography, X-RayHLA-A2 AntigenHLA-B7 AntigenHumansPhosphoproteinsReceptors, Antigen, T-CellSpike Glycoprotein, CoronavirusCoronavirus Nucleocapsid ProteinsEpitopes, T-LymphocyteHLA-A2 AntigenHLA-B7 AntigenImmunodominant Epitopesnucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsReceptors, Antigen, T-CellSpike Glycoprotein, Coronavirus

Identifiers

PMID41372155
PMCPMC12749039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.