Evidence map›Paper›PMID 41372129›Full record

ReviewCell death discovery2025

Circulating tumor cells in breast cancer bone metastasis: mechanisms, clinical relevance, and future directions.

Lingfeng Ma, Yufei Wang, Shuying Qiu, Min Shi, Wanfen Tang, Hangqi Hu, Chentao Li, Haiqi Lu, Xian Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. METTL3-YTHDF1-driven mMolecular and cellular biochemistry · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lingfeng Ma *Department of Medical Oncology, Sir Run Run Shaw hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Yufei Wang *Department of Medical Oncology, Sir Run Run Shaw hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Shuying Qiu *Department of Medical Oncology, Sir Run Run Shaw hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Min ShiDepartment of Medical Oncology, Zhejiang Putuo Hospital, Zhoushan, Zhejiang Province, China.
Wanfen TangDepartment of Medical Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Hangqi HuDepartment of Medical Oncology, Sir Run Run Shaw hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Chentao LiDepartment of Pathology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Haiqi LuDepartment of Medical Oncology, Sir Run Run Shaw hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. haiqilu@zju.edu.cn.
Xian WangDepartment of Medical Oncology, Sir Run Run Shaw hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. wangx118@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating tumor cells (CTCs) play a critical role in the metastatic cascade and have emerged as promising biomarkers for cancer diagnosis, prognosis, and therapeutic monitoring. In breast cancer, CTCs mediate bone metastasis through intricate interactions with the bone microenvironment, regulating process such as homing, dormancy, reactivation, and colonization. Advances in CTC detection and characterization have deepened our understanding of their physical and biological properties, yet significant technical and biological challenges remain. This review provides a comprehensive overview of the roles of CTCs in breast cancer bone metastasis and highlighting their clinical significance, current limitations, and future applications.

Identifiers

PMID41372129
PMCPMC12830773

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.