Evidence map›Paper›PMID 41372127›Full record

ArticleNature communications2025

Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic.

Samantha J Bents, Emily T Martin, Terry Stevens-Ayers, Claire Andrews, Amanda Adler, Amanda C Perofsky, Elizabeth M Krantz, Rachel Blazevic, Louise Kimball, Robin Prentice and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Samantha J BentsDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA. sjbents@stanford.edu.ORCID http://orcid.org/0009-0003-9298-945X
Emily T MartinDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Terry Stevens-AyersVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7546-8439
Claire AndrewsVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Amanda AdlerDivision of Pediatric Infectious Diseases, Seattle Children's Hospital, Seattle, WA, USA.
Amanda C PerofskyFogarty International Center, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7341-9193
Elizabeth M KrantzVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Rachel BlazevicVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Louise KimballVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Robin PrenticeVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7882-1050
Chelsea HansenFogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Lea StaritaBrotman Baty Institute, University of Washington, Seattle, WA, USA.
Peter HanBrotman Baty Institute, University of Washington, Seattle, WA, USA.
Janet A EnglundDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1134-4178
Nicole WolterCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-9526-0133
Anne von GottbergCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-0243-7455
Lorens MaakeCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Jocelyn MoyesCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Cheryl CohenCentre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.ORCID http://orcid.org/0000-0003-0376-2302
Michael BoeckhVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1538-7984
James A HayPandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID http://orcid.org/0000-0002-1998-1844
Alpana WaghmareVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cécile ViboudFogarty International Center, National Institutes of Health, Bethesda, MD, USA. viboudc@mail.nih.gov.ORCID http://orcid.org/0000-0003-3243-4711

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HENSLEY, SCOTT · 2021 to 2025
$50.7M
NIAID NIH HHS 75N93021C00015Wellcome Trust
6 · The paper itself

Abstract

The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt. We assessed age-specific antibody dynamics across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2 using serology collected in King County, Washington, US, from 2020-2022 (n = 1508). We found that respiratory virus immunodynamics differed between individuals <5 years of age and older individuals, with young children experiencing larger boosts and quicker waning of antibodies across pathogens. We confirmed that these patterns are upheld in a non-pandemic setting by analyzing influenza serology collected in South Africa between 2016-2018 (n = 1028). We incorporated our serological insights into an influenza transmission model calibrated to epidemiological data from King County and show that consideration of age-specific immunodynamics may be important to anticipate the effects of pandemic perturbations.

Indexed as

Antibodies, ViralCOVID-19AdolescentAdultAgedAge FactorsChildChild, PreschoolFemaleHumansInfantInfluenza, HumanMaleMiddle AgedPandemicsSARS-CoV-2Antibodies, Viral

Identifiers

PMID41372127
PMCPMC12695953

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.