Evidence map›Paper›PMID 41371963›Full record

ArticleGenome research2026

Cell-type- and chromosome-specific chromatin landscapes and DNA replication programs of

Jennifer A Urban, Daniel Ringwalt, John M Urban, Wingel Xue, Ryan Gleason, Keji Zhao, Xin Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jennifer A UrbanDepartment of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA; jenurbanphd@gmail.com xchen32@jhu.edu.ORCID 0000-0002-6621-8358
Daniel RingwaltDepartment of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0009-0004-2728-3933
John M UrbanHoward Hughes Medical Institute, Baltimore, Maryland 21218, USA.ORCID 0000-0001-9270-6569
Wingel XueDepartment of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0002-9076-5829
Ryan GleasonDepartment of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA.ORCID 0000-0002-3859-1390
Keji ZhaoSystems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Xin ChenDepartment of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA; jenurbanphd@gmail.com xchen32@jhu.edu.ORCID 0000-0002-6990-0926

Funding

Study epigenetic inheritance during development, homeostasis and regenerationR35GM127075 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Xin Chen · 2018 to 2026
$3.2M
Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell LineageR01HD102474 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CHEN, XIN · 2020 to 2024
$1.7M
Contribution of DNA replication to epigenetic inheritance in a model multi-cellular organismK99GM145973 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI URBAN, JENNIFER ANNE · 2022 to 2023
$225k
NICHD NIH HHS R01 HD102474NIGMS NIH HHS K99 GM145973NIGMS NIH HHS R35 GM127075
6 · The paper itself

Abstract

Stem cells have the unique ability to self-renew and differentiate into specialized cell types. Epigenetic mechanisms, including histones and their post-translational modifications, play a crucial role in regulating programs integral to a cell's identity, like gene expression and DNA replication. However, the transcriptional, chromatin, and replication timing profiles of adult stem cells in vivo remain poorly understood. Containing germline stem cells (GSCs) and somatic cyst stem cells (CySCs), the

Indexed as

ChromatinDNA ReplicationNeoplastic Stem CellsTestisAnimalsDrosophilaDrosophila melanogasterHistonesMaleChromatinHistones

Identifiers

PMID41371963
PMCPMC12758400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.