Evidence map›Paper›PMID 41371955›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

The Retinal Light Response Is Modulated by an mGluR5-Mediated Retrograde Signal from ON-Bipolar Cells to Photoreceptors.

Catherine W Morgans, Tammie L Haley, Gaoying Ren, Ian A M Taylor, Kate L Randall, Robert M Duvoisin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Catherine W MorgansDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239.ORCID 0000-0002-7287-3447
Tammie L HaleyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239.
Gaoying RenDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239.
Ian A M TaylorDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239.
Kate L RandallDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239.
Robert M DuvoisinDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon 97239 duvoisin@ohsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ON visual pathway is initiated by the deactivation of mGluR6, coupled to the opening of TRPM1 channels in retinal ON-bipolar cell dendrites. Here, we show that a second metabotropic glutamate receptor, mGluR5, is localized with TRPM1 and mGluR6 in the dendrites of ON-bipolar cells. To examine the function of mGluR5, we performed electroretinogram (ERG) recordings in mice of either sex and found that the amplitude of the b-wave, which is primarily a measure of ON-bipolar cell light-driven activity, is reduced in mGluR5 knock-out mice compared with wild type. In the mGluR5

Indexed as

Photoreceptor Cells, VertebrateReceptor, Metabotropic Glutamate 5RetinaRetinal Bipolar CellsAnimalsElectroretinographyFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPhotic StimulationReceptors, Metabotropic GlutamateSignal TransductionTRPM Cation ChannelsVisual PathwaysGrm5 protein, mousemetabotropic glutamate receptor 6Receptor, Metabotropic Glutamate 5Receptors, Metabotropic GlutamateTrpm1 protein, mouseTRPM Cation Channelscannabinoidelectroretinogramglutamateimmunohistochemistrymetabotropicretina

Identifiers

PMID41371955
PMCPMC12809660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.