ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity.
Casey Dalton, Jelena Mojsilovic-Petrovic, Nathaniel Safren, Carley Snoznik, Kamil K Gebis, Yi-Zhi Wang, Alexandra B Sutter, Todd Lamitina, Jeffrey N Savas, Robert G Kalb
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Casey DaltonDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611.
Jelena Mojsilovic-PetrovicDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611.
Nathaniel SafrenDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611.
Carley SnoznikDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Kamil K GebisDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611.
Yi-Zhi WangDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611.ORCID 0000-0001-5279-5034
Alexandra B SutterDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611.
Todd LamitinaDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania 15224.
Jeffrey N SavasDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611.ORCID 0000-0002-8173-5580
Robert G KalbDepartment of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60611 robert.kalb1@northwestern.edu.
Funding
Mechanistic Analysis of Genetic Modifiers in Parkinson's DiseaseR35NS122257 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DIMITRI KRAINC · 2021 to 2026
$6.8M
Defining mechanisms underlying C9orf72-associated frontotemporal dementia with C. elegans and mammalian modelsR01NS124802 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Robert G Kalb, SAMUEL T LAMITINA · 2022 to 2026
$3.6M
RAD23 Control of ALS phenotypesR01NS122908 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KALB, ROBERT G · 2021 to 2025
$2.0M
Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration HubS10OD032464 · OD · NORTHWESTERN UNIVERSITY · PI SAVAS, JEFFREY NICHOLAS · 2023 to 2023
$1.3M
Mechanisms of chemotherapy-evoked neuropathic painR01NS052255 · NINDS · MCGILL UNIVERSITY · PI BENNETT, GARY J · 2006 to 2009
$815k
ERAD genes that suppress neurodegenerationR21NS087077 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI KALB, ROBERT G · 2014 to 2015
At autopsy, >95% of ALS cases display a redistribution of the essential RNA binding protein TDP-43 from the nucleus into cytoplasmic aggregates. The mislocalization and aggregation of TDP-43 is believed to be a key pathological driver in ALS. Due to its vital role in basic cellular mechanisms, direct depletion of TDP-43 is unlikely to lead to a promising therapy. Therefore, we have explored the utility of identifying genes that modify its mislocalization or aggregation. We have previously shown that loss of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity. · full record | OpenQuestion