Evidence map›Paper›PMID 41371926›Full record

ArticleBMJ global health2025

Rapid establishment of public sector COVID-19 test-and-treatment programmes across seven low- and middle-income countries: implementation strategies and program monitoring results.

Caroline E Boeke, Nervine Hamza, Chukwuemeka Agwuocha, Okechukwu Amako, Khamsay Detleuxay, Michelle Gao, Bridget C Griffith, Yamikani Gumulira, Elina Urli Hodges, Jessica Joseph and 18 more

Abstract read
In one paragraph

Article in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Caroline E BoekeClinton Health Access Initiative, Boston, Massachusetts, USA caroline.boeke@mail.harvard.edu.ORCID 0000-0003-1939-1307
Nervine HamzaClinton Health Access Initiative, Boston, Massachusetts, USA.
Chukwuemeka AgwuochaClinton Health Access Initiative, Abuja, Nigeria.
Okechukwu AmakoClinton Health Access Initiative, Boston, Massachusetts, USA.
Khamsay DetleuxayMahosot Hospital, Vientiane City, Lao PDR, Vientiane, Lao People's Democratic Republic.
Michelle GaoClinton Health Access Initiative, Boston, Massachusetts, USA.
Bridget C GriffithClinton Health Access Initiative, Boston, Massachusetts, USA.
Yamikani GumuliraClinton Health Access Initiative, Lilongwe, Malawi.
Elina Urli HodgesDuke Global Health Institute, Duke University, Durham, North Carolina, USA.ORCID 0000-0001-8378-3378
Jessica JosephClinton Health Access Initiative, Boston, Massachusetts, USA.ORCID 0000-0002-3860-4673
Norman LufesiAcute Respiratory Illness Unit, Government of Malawi Ministry of Health, Lilongwe, Malawi.
Emily MachariaDuke Global Health Institute, Duke University, Durham, North Carolina, USA.
Nyuma MbeweZambia National Public Health Institute, Lusaka, Zambia.ORCID 0000-0002-3309-0538
Elizabeth McCarthyClinton Health Access Initiative, Boston, Massachusetts, USA.
Faustina O MintahClinton Health Access Initiative, Accra, Ghana.
Moses MukiibiQuality Assurance, Uganda Ministry of Health Pharmacy Division, Kampala, Uganda.
Mwaba MulengaClinton Health Access Initiative, Lusaka, Zambia.
Alida NgwijeClinton Health Access Initiative, Kigali, Rwanda.
Lawrence Ofori-BoaduInstitutional Care Division, Ghana Health Service, Accra, Greater Accra Region, Ghana.
Ijeoma Uzondu OkoliNigeria Federal Ministry of Health, Abuja, FCT, Nigeria.
Sompasong PhongphilaClinton Health Access Initiative, Vientiane, Lao People's Democratic Republic.
Christian RamersClinton Health Access Initiative, Boston, Massachusetts, USA.
Sean ReganClinton Health Access Initiative, Boston, Massachusetts, USA.
Evarist TwinomujuniClinton Health Access Initiative, Kampala, Uganda.ORCID 0009-0000-2500-6554
Edison RwagasoreRwanda Biomedical Center, Rwanda Ministry of Health, Kigali, Rwanda.
Jessica TeborClinton Health Access Initiative, Boston, Massachusetts, USA.
Krishna UdayakumarDuke Global Health Institute, Duke University, Durham, North Carolina, USA.ORCID 0000-0001-8954-4343
COVID-19 Treatment QuickStart Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 Treatment QuickStart Consortium worked with governments in seven low- and middle-income countries (LMICs), Ghana, Laos, Malawi, Nigeria, Rwanda, Uganda and Zambia, to implement COVID-19 test-and-treat programmes at 776 health facilities, including training over 5000 staff and facilitating a donation of 11 300 courses of the oral antiviral nirmatrelvir/ritonavir for treatment. This paper describes the process of implementing COVID-19 test-and-treat programmes in each country, provides aggregate programme monitoring data on numbers tested and treated and analyzes programme enablers and challenges. Between country-level programme initiation (Ghana, May 2023; Laos and Malawi, July 2023; Nigeria, June 2023; Rwanda, March 2023; Uganda, September 2023; Zambia, December 2022) and June 2024, a total of 731 970 SARS-CoV-2 tests were conducted. Of 6724 positive tests, a subset were documented to meet eligibility criteria for nirmatrelvir/ritonavir initiation, and 3041 patients were prescribed nirmatrelvir/ritonavir. The largest number of prescriptions was in Zambia. Programme enablers included decentralisation of services; task-shifting from higher to lower health worker cadres; increased access to point of care antigen tests, including self-tests; and the integration of COVID-19 with other health services. Challenges included COVID-19 de-prioritisation at the time of programme rollout, test commodity stockouts and expiries, and dwindling national surveillance efforts. Learnings from rapid initiation and scale-up of COVID-19 test-and-treat programmes in these seven countries can be used to inform future pandemic preparedness strategies in LMICs.

Indexed as

COVID-19COVID-19 Drug TreatmentCOVID-19 TestingDeveloping CountriesPublic SectorAntiviral AgentsHumansRitonavirSARS-CoV-2Antiviral AgentsRitonavirAfricaCOVID-19Pandemic Preparedness

Identifiers

PMID41371926
PMCPMC12699579

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.