ArticleKorean circulation journal2026
Real-World Efficacy of Tafamidis in Korean ATTR-CM Patients: A Retrospective Observational Strain Analysis.
Article in Korean circulation journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Tafamidis in the Contemporary Management of Transthyretin Cardiac Amyloidosis: A Systematic Review.Journal of clinical medicine · 2026Review
- The First Korean Clinical Evidence With Tafamidis in ATTR-CM.Korean circulation journal · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesTransthyretin amyloid cardiomyopathy (ATTR-CM) is an under-recognized condition with high mortality if untreated. Tafamidis, a transthyretin stabilizer, reduces mortality and cardiovascular events in ATTR-CM, but data in Korean populations are limited. This study evaluated the impact of tafamidis on survival and disease progression in Korean ATTR-CM patients using strain analysis of the left ventricle (LV), right ventricle (RV) and left atrium (LA).
methodsThis multicenter, retrospective study included 77 patients with confirmed ATTR-CM between July 2010 and June 2024. Patients were grouped as untreated or treated with tafamidis 20 mg or 80 mg. Strain analysis was performed at baseline and follow-up. The primary outcome was a composite of all-cause mortality and worsening heart failure.
resultsCompared with the untreated group, the tafamidis 20 mg group had a lower risk of the composite outcome (hazard ratio [HR], 0.29; 95% confidence interval [CI], 0.12, 0.73), with similar benefit in the 80 mg group (HR, 0.23; 95% CI, 0.06, 0.83). LV global longitudinal strain showed no significant difference (p=0.904). In contrast, LA stiffness index (LASI) and RV-pulmonary circulation coupling index deteriorated markedly in the untreated group. Over a median follow-up of 17.5 months, LASI worsened by 43.2% in the untreated group, compared to 8.0% and 8.7% increases in the 20 mg and 80 mg groups. RV-pulmonary circulation coupling index decreased by 35.8% and 1.2%, but increased by 10.9%, respectively.
conclusionsTafamidis was associated with improved survival and slower disease progression in Korean ATTR-CM. LASI and RV-pulmonary circulation coupling index may serve as sensitive markers of treatment response.
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