Evidence map›Paper›PMID 41371746›Full record

ArticleBMJ open2025

Effect of peri-interventional music on postictal agitation in electroconvulsive therapy patients (MUSE): protocol for an open-label multicentre randomised controlled trial in the Netherlands.

Emilie S van der Valk Bouman, Melissa Ertman, Michel R Koopmans, Joris J B van der Vlugt-Molenaar, Willemijn T C J Heijnen, Jasmijn C van Groen, Jan-Wiebe Korstanje, Tom K Birkenhager, Markus Klimek

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06817330 (the Effect of a MUsic Intervention on poStictal Agitation in Electroconvulsive Therapy Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06817330 narecruitingnot on this map

the Effect of a MUsic Intervention on poStictal Agitation in Electroconvulsive Therapy Patients: the MUSE Trial

TypeinterventionalSponsorErasmus Medical CenterRan2025 to 2027Enrolled92ConditionsMusic Intervention, Electroconvulsive Therapy Treated Patients, Agitation on Recovery From SedationArmsIntervention group, listening to recorded music, Control group, headphones with no music
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emilie S van der Valk Bouman *Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands e.vandervalkbouman@erasmusmc.nl.ORCID http://orcid.org/0000-0001-7807-4390
Melissa Ertman *Department of Anesthesiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Michel R KoopmansDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
Joris J B van der Vlugt-MolenaarDepartment of Psychiatry, Antes Parnassia, Maasstad Ziekenhuis, Rotterdam, The Netherlands.
Willemijn T C J HeijnenDepartment of Psychiatry, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Jasmijn C van GroenDepartment of Psychiatry, Antes Parnassia, Maasstad Ziekenhuis, Rotterdam, The Netherlands.
Jan-Wiebe KorstanjeDepartment of Anesthesiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Tom K BirkenhagerDepartment of Psychiatry, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Markus KlimekDepartment of Anesthesiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0122-9929

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostictal agitation (PIA) is a common adverse effect following electroconvulsive therapy (ECT). Current pharmacological treatments for PIA have undesirable side effects, and interventions to prevent PIA are unsatisfactory. The aim of this study is to assess the effect of peri-interventional music on PIA for patients undergoing ECT. Additionally, the study will assess the impact of music on pretreatment anxiety and post-treatment cognitive impairment. METHODS AND ANALYSIS: This multicentre, open-label, parallel randomised controlled trial (RCT) aims to include 92 patients from two centres in Rotterdam, the Netherlands. Participants will be randomised into two groups: a music intervention group and a control group. The music group listens to recorded music 30 min before and 12 min after each of the first six ECT sessions of the full ECT course, while the control group will receive standard care. The primary outcome is the presence of PIA, measured using the Richmond Agitation-Sedation Scale (RASS). Secondary outcomes include the severity and duration of PIA, pretreatment anxiety, recovery duration, peri-treatment medication requirements, cognitive impairment and depression severity. Data will be analysed according to an intention-to-treat principle. ETHICS AND DISSEMINATION: This study protocol has been approved by the Medical Ethical Review Committee of the Erasmus Medical Centre on 28 January 2025 (MEC-2024-0467) and subsequently received local approval at Antes Parnassia group. The trial will be carried out following the Declaration of Helsinki principles. Study results will be reported in a peer-reviewed journal according to the Consolidated Standards of Reporting Trials guidelines. TRIAL REGISTRATION NUMBER: NCT06817330.

Indexed as

Electroconvulsive TherapyMusic TherapyPsychomotor AgitationAdultAnxietyFemaleHumansMaleMiddle AgedMulticenter Studies as TopicNetherlandsRandomized Controlled Trials as TopicAdult anaesthesiaAdult psychiatryPSYCHIATRYRandomized Controlled Trial

Identifiers

PMID41371746
PMCPMC12699561

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.