Evidence map›Paper›PMID 41371741›Full record

ArticleBMJ open2025

Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: a prospective cohort study protocol.

Maya Campbell, Josephine I Lafayette, Karina Vallejo Vasquez, Ava Rivard, Jordan Diamond, Clarence Nguyen, Dominick Caputo, Sahana Lothumalla, Chavez R Rodriguez, Devin C Tomlinson and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exploring risk tolerance among individuals who use opioids.Experimental and clinical psychopharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maya CampbellAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0009-0008-6512-1563
Josephine I LafayetteAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Karina Vallejo VasquezAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Ava RivardAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Jordan DiamondAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Clarence NguyenAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Dominick CaputoAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Sahana LothumallaAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Chavez R RodriguezAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Devin C TomlinsonAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Erin E BonarAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Jason E GoldstickInjury Prevention Center, University of Michigan, Ann Arbor, Michigan, USA.
Maureen WaltonAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Sunghee LeeInstitute for Social Research (ISR), University of Michigan, Ann Arbor, Michigan, USA.
Nathan MenkeAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Lewei Allison LinAddiction Center, University of Michigan, Ann Arbor, Michigan, USA.
Lara N CoughlinAddiction Center, University of Michigan, Ann Arbor, Michigan, USA laraco@med.umich.edu.

Funding

MULTIDISCIPLINARY ALCOHOLISM RESEARCH TRAINING PROGRAMT32AA007477 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maureen A. Walton · 1990 to 2026
$7.4M
Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: Implications for improving careR01DA057591 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lara Nicole Coughlin, Lewei Allison Lin · 2022 to 2026
$3.9M
Improving Reproducibility of Respondent Driven Sampling through Adaptive Design - Diversity SupplementR01AG060936 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEE, SUNG-HEE · 2019 to 2023
$2.2M
NIAAA NIH HHS T32 AA007477NIA NIH HHS R01 AG060936NIDA NIH HHS R01 DA057591
6 · The paper itself

Abstract

introductionPolysubstance use (PSU), particularly opioid-involved and stimulant-involved PSU, is a growing issue in the USA. PSU increases the risk of negative health consequences, including infectious diseases, worsening physical and mental health conditions, and overdose-related deaths. These consequences occur in the context of varying health risk behaviours, substance-related preferences, and treatment engagements among people with PSU. To inform improvements in prevention, harm reduction, and substance use disorder (SUD) treatment, additional research is needed to comprehensively understand the current context and drivers of PSU preferences, motivations, and behaviours. METHODS AND ANALYSIS: Herein, we describe the protocol for a prospective cohort study designed to capture detailed patterns, profiles, and trajectories of PSU, with the aim of comprehensively examining the drivers of PSU behaviours and SUD treatment utilisation. Adults (ages 18-75; n=400) who engage in PSU will be recruited from healthcare institutions, an established participant database maintained by an adjacent SUD research team, and online advertisements. Study assessments will capture dynamic patterns, choice preferences, and motivators of PSU via behavioural economic (BE) measures, detailed Timeline Follow-Back (TLFB) interviews, and self-administered surveys. The assessment timeline will include a baseline survey and TLFB interview, weekly TLFB interviews for 4 weeks post-baseline, and follow-up surveys and TLFB interviews at 4-, 8-, and 12-months post-baseline. ETHICS AND DISSEMINATION: The study is funded through the National Institutes of Health Helping to End Addiction Long-term (HEAL) initiative and was approved by the University of Michigan Medical Institutional Review Board. Findings will be disseminated to academic, clinical, and community partners through the Michigan Innovations in Addiction Care through Research and Education programme. Results from this study will inform actionable and practical insights relevant to the delivery of personalised care in the context of PSU.

Indexed as

Analgesics, OpioidOpioid-Related DisordersPatient PreferenceSubstance-Related DisordersAdolescentAdultAgedFemaleHarm ReductionHumansMaleMiddle AgedMotivationProspective StudiesResearch DesignUnited StatesAnalgesics, OpioidAdult psychiatryHEALTH ECONOMICSSubstance misuse

Identifiers

PMID41371741
PMCPMC12699772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.