Antiviral activity of Staphylococcus aureus V8 protease against bovine alphaherpesvirus-1 in vitro.

Sumiya Borjigin, Yuka Nunomura, Koji Nishifuji, Tetsuya Mizutani, Mami Oba

Abstract read

In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sumiya BorjiginCenter for Infections Disease of Epidemiology and Prevention Research (CEPiR), Tokyo University of Agriculture and Technology, Tokyo, Japan.

Yuka NunomuraCenter for Infections Disease of Epidemiology and Prevention Research (CEPiR), Tokyo University of Agriculture and Technology, Tokyo, Japan.

Koji NishifujiDivision of Animal Life Science, Institute of Agriculture, Graduate School, Tokyo University of Agriculture and Technology, Tokyo, Japan.

Tetsuya MizutaniCenter for Infections Disease of Epidemiology and Prevention Research (CEPiR), Tokyo University of Agriculture and Technology, Tokyo, Japan.

Mami ObaCenter for Infections Disease of Epidemiology and Prevention Research (CEPiR), Tokyo University of Agriculture and Technology, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human and other mammals harbor diverse commensal bacteria that may protect their hosts from invading pathogens. Here, we demonstrated that Staphylococcus aureus V8 protease significantly suppressed bovine alphaherpesvirus-1 (BHV-1) infectivity in vitro. V8 protease exhibited concentration-dependent antiviral activity by degrading BHV-1 glycoprotein D (gD), essential for viral entry. Treatment with V8 protease inhibited both viral attachment and the infectivity of released virions, suppressing incoming viruses and limiting spread during established infections. These findings reveal that proteases from commensal bacteria can directly target major viral proteins. However, to deepen our understanding of the antiviral activity of commensal bacterial enzymes on the body surface, establishing methods to measure the quantity of specific enzymes is urgently needed.

Indexed as

Antiviral AgentsBacterial ProteinsHerpesvirus 1, BovinePeptide HydrolasesStaphylococcus aureusAnimalsCattleAntiviral AgentsBacterial ProteinsPeptide Hydrolasesantiviral activitydegrade bovine alphaherpesvirus-1 gDStaphylococcus aureusV8 protease

Identifiers

PMID41371690

DOI10.1292/jvms.25-0364

PMCPMC12887106

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.