ArticleInternal medicine (Tokyo, Japan)2026
Preventive Effectiveness of Recombinant Zoster Vaccine in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Vaccination considerations in autoimmune rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Japanese evidence on Janus kinase inhibitors for rheumatoid arthritis: a narrative review of risk-optimized use.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective This study assessed the effectiveness of the recombinant zoster vaccine (RZV) in preventing herpes zoster (HZ) in rheumatoid arthritis (RA) patients treated with Janus kinase (JAK) inhibitors. Methods This was a retrospective analysis. The patients were categorized into vaccinated (n=74) and unvaccinated (n=120) groups. HZ incidence was compared using the Kaplan-Meier method, and vaccine effectiveness was estimated using inverse probability of treatment weighting (IPTW) to adjust for baseline confounding factors. Patients 194 Japanese RA patients were analyzed treated with JAK inhibitors at our institution from January 2020 to September 2024. Results The observation spanned 124.4 person-years in the vaccinated group and 256.2 in the unvaccinated group. HZ occurred in six vaccinated cases (4.8 per 100 person-years) versus 20 unvaccinated cases (7.8 per 100 person-years) (p=0.32). The overall efficacy of the vaccine was 59.1%. HZ incidence varied by JAK inhibitor: baricitinib (5.5 vs 9.9), upadacitinib (12.4 vs 6.2), and filgotinib (0.0 vs 1.6) per 100 person-years. Vaccinated patients who developed HZ had significantly lower lymphocyte counts and higher SDAI and CDAI scores. Conclusion Although not statistically significant, RZV vaccination tended to reduce the incidence of HZ in Japanese RA patients receiving JAK inhibitors. The effectiveness varied according to the type of JAK inhibitor, with lower lymphocyte counts and higher disease activity, and it may predict insufficient protection.
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