Evidence map›Paper›PMID 41371621›Full record

ArticleNMR in biomedicine2026

Validation of Dynamic Deuterium Metabolic Imaging (DMI) for the Measurement of Cerebral Metabolic Rates of Glucose in Rat.

Claudius S Mathy, Monique A Thomas, Graeme F Mason, Robin A de Graaf, Henk M De Feyter

Abstract readValidation Study
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Claudius S MathyDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA.
Monique A ThomasDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA.
Graeme F MasonDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA.
Robin A de GraafDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA.
Henk M De FeyterDepartment of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-6111-0316

Funding

Validation of imaging brain tumor metabolism using deuterated glucoseR01EB033764 · NIBIB · YALE UNIVERSITY · PI ROBIN A DE GRAAF, Henk De Feyter · 2023 to 2026
$2.4M
Single-scan, multi-contrast imaging of glucose metabolism in patients with glioblastomaR01CA288833 · NCI · YALE UNIVERSITY · PI Henk De Feyter · 2025 to 2026
$1.4M
Mapping of choline uptake and metabolism in brain tumors with deuterium metabolic imaging (DMI)R03CA267438 · NCI · YALE UNIVERSITY · PI DE FEYTER, HENK · 2023 to 2024
$168k
Deutsche Forschungsgemeinschaft 493624887 (Clinician Scientist Program NOTICE)NCI NIH HHS R01 CA288833NCI NIH HHS R03 CA267438NIBIB NIH HHS R01 EB033764US National Institutes of Health R01CA288833US National Institutes of Health R01EB025840US National Institutes of Health R01EB033764
6 · The paper itself

Abstract

Deuterium metabolic imaging (DMI) is an innovative technique in which

Indexed as

BrainDeuteriumGlucoseMagnetic Resonance ImagingAnimalsCarbon IsotopesMagnetic Resonance SpectroscopyMaleRatsRats, Sprague-DawleyReproducibility of ResultsCarbon IsotopesDeuteriumGlucosedeuterium metabolic imaging (DMI)metabolic modelingMRS

Identifiers

PMID41371621
PMCPMC12695439

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.