Evidence map›Paper›PMID 41371359›Full record

ArticleJournal of affective disorders2026

Mental disorders & self-injurious thoughts and behaviors predict high risk of role impairment among university students - results from the world mental health international college student initiative.

Jordi Alonso, Maria V Petukhova, Sue Lee, Nancy A Sampson, Yasmin A Altwaijri, Ahmad N AlHadi, Nouf K Al-Saud, Claes Andersson, Randy P Auerbach, Laura Ballester and 40 more

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Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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50 authors.

Jordi AlonsoHealth Services Research Group, Hospital del Mar Research Institute, Carrer del Doctor Aiguader, 88 08003, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III (CIBERESP, ISCIII), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.; Department of Medicine and Life Sciences, Pompeu Fabra University (UPF), Barcelona, Spain. Electronic address: jordi.alonso@upf.edu.
Maria V PetukhovaDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Sue LeeDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Nancy A SampsonDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
Yasmin A AltwaijriBiostatistics, Epidemiology and Scientific Computing Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ahmad N AlHadiDepartment of Psychiatry, College of Medicine, King Saud University, Riyadh, Saudi Arabia; SABIC Psychological Health Research & Applications Chair (SPHRAC), Department of Psychiatry, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Nouf K Al-SaudBiostatistics, Epidemiology and Scientific Computing Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Claes AnderssonDepartment of Criminology, Malmö University, Malmö, Sweden.
Randy P AuerbachDepartment of Psychiatry, Columbia University, New York, NY, USA.
Laura BallesterHealth Services Research Group, Hospital del Mar Research Institute, Carrer del Doctor Aiguader, 88 08003, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III (CIBERESP, ISCIII), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.
Jason BantjesMental Health, Alcohol, Substance Use and Tobacco Research Unit, South African Medical Research Council, Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Institute for Life Course Health Research, Global Health, Stellenbosch University, South Africa.
Marcus BendtsenDepartment of Health, Medicine and Caring Sciences, Linköping University, Linkoping, Sweden.
Corina BenjetCenter for Global Mental Health Research, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.
Anne H BermanDepartment of Psychology, Uppsala University, Uppsala, Sweden.
Paula CarrascoCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III (CIBERESP, ISCIII), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.; Department of Medicine, Universitat Jaume I, Castellón de la Plana, Spain; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
Silver C N ChanThe Hong Kong University of Science and Technology, Hong Kong.
Irina CohutCareer Counseling and Guidance Center, Technical University of Cluj-Napoca, Romania.
Marcelo A CrockettNucleus to Improve the Mental Health of Adolescents and Youths (Imhay), Santiago, Chile.
Pim CuijpersFaculty of Behavioural and Movement Science, Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit Amsterdam, the Netherlands; Department of Clinical Psychology and Psychotherapy, Babes-BOlyai University, Cluj-Napoca, Romania.
Oana A DavidDATA Lab, International Institute for Advanced Studies in Psychotherapy and Applied Mental Health, Babeș-Bolyai University, Cluj-Napoca, Romania.
Dong DongThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Jorge GaeteNucleus to Improve the Mental Health of Adolescents and Youths (Imhay), Santiago, Chile; Centro de Investigación en Salud Mental Estudiantil (ISME), Facultad de Ciencias Sociales, Universidad de los Andes, Santiago, Chile.
Mireia Felez-NobregaParc Sanitari Sant Joan de Deu, Institut de Recerca Sant Joan de Deu (IRSJD), Sant Boi de Llobregat, Barcelona, Spain.
Carlos García ForeroDepartamento de Medicina, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Margalida GiliDepartment of Psychology, University of the Balearic Islands (UIB), Palma, Mallorca, Spain.
Raúl A Gutiérrez-GarcíaFaculty of Higher Education Universidad La Salle Bajío, campus Salamanca, Mexico.
Josep Maria HaroParc Sanitari Sant Joan de Deu, Institut de Recerca Sant Joan de Deu (IRSJD), Sant Boi de Llobregat, Barcelona, Spain; Centro de investigación Biomédica en Red en Salud Mental (CIBERSAM), ISCIII, Madrid, Spain.
Xanthe HuntMental Health, Alcohol, Substance Use and Tobacco Research Unit, South African Medical Research Council, Cape Town, South Africa; Africa Health Research Institute (AHRI), Durban, South Africa.
Álvaro I LangerNucleus to Improve the Mental Health of Adolescents and Youths (Imhay), Santiago, Chile; Facultad de Psicología y Humanidades, Universidad San Sebastián, Santiago, Chile.
Irene LénizDirección de Salud Mental, Universidad de O'Higgins, Rancagua, Chile.
Yan LiuSchool of Public Health, Jining Medical University, Jining, 272067, Shandong Province, PR China.
Scarlett Mac-GintyNucleus to Improve the Mental Health of Adolescents and Youths (Imhay), Santiago, Chile; Department of Health Service & Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Vania MartínezNucleus to Improve the Mental Health of Adolescents and Youths (Imhay), Santiago, Chile; Centro de Medicina Reproductiva y Desarrollo Integral del Adolescente (Cemera), Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Andre MasonSchool of Psychological and Social Sciences, University of Waikato, Hamilton, New Zealand.
Andrea Miranda-MendizabalCentro de investigación Biomédica en Red en Salud Mental (CIBERSAM), ISCIII, Madrid, Spain; Sant Joan de Déu Research Institute, Carrer de Santa Rosa, 39-57, 08950, Esplugues del Llobregat, Spain.
Daniel NúñezNucleus Imhay, Santiago, Chile; Facultad de Psicología, Universidad de Talca, Talca, Chile.
Claudiu C PapasteriDepartment of Psychology and Cognitive Sciences, University of Bucharest, Romania.
José A PiquerasDepartment of Health Psychology, Universidad Miguel Hernandez de Elche (UMH), Alicante, Spain.
Codruta A PopescuDepartment of Human Sciences, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Charlene RapseyDepartment of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Tiscar Rodriguez-JimenezDepartment of Psychology and Sociology, Universidad de Zaragoza (UNIZAR), Zaragoza, Spain.
Wylene SaalDepartment of Social Sciences, Sol Plaatje University, South Africa.
Oi-Ling SiuDepartment of Psychology, Lingnan University, Hong Kong.
Dan J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa.
Sascha Y StruijsFaculty of Behavioural and Movement Science, Department of Clinical, Neuro- and Developmental Psychology, Vrije Universiteit Amsterdam, the Netherlands.
Cristina T TomoiagaDATA Lab, International Institute for Advanced Studies in Psychotherapy and Applied Mental Health, Babeș-Bolyai University, Cluj-Napoca, Romania.
Samuel Y S WongThe Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Gemma VilagutHealth Services Research Group, Hospital del Mar Research Institute, Carrer del Doctor Aiguader, 88 08003, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III (CIBERESP, ISCIII), Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USA.
World Mental Health International College Student collaborators

Funding

Risk Factors for Psychopathology in the WHO WMH SurveysR01MH070884 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 2005 to 2009
$6.0M
Social Role Disability and Mental-Physical Co-MorbidityR01MH069864 · NIMH · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI VON KORFF, MICHAEL R · 2004 to 2007
$2.2M
CROSS-NATIONAL STUDIES OF DRUG INVOLVEMENT: WMH2000R01DA016558 · NIDA · MICHIGAN STATE UNIVERSITY · PI ANTHONY, JAMES CHRISTOPHER · 2003 to 2008
$1.7M
World Mental Health Consortium Annual Meeting 2003-07R13MH066849 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEERINGA, STEVEN G · 2003 to 2007
$735k
Predicting Internet-Based Treatment Response for Major Depressive DisorderR56MH109566 · NIMH · MCLEAN HOSPITAL · PI AUERBACH, RANDY PATRICK · 2016 to 2017
$685k
Lebanon-Epidemiology: The NCS Replication StudyR03TW006481 · FIC · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI KESSLER, RONALD C · 2004 to 2006
$142k
FIC NIH HHS R03 TW006481NIDA NIH HHS R01 DA016558NIMH NIH HHS R01 MH069864NIMH NIH HHS R01 MH070884NIMH NIH HHS R13 MH066849NIMH NIH HHS R56 MH109566Wellcome Trust
6 · The paper itself

Abstract

objectiveWe examined psychopathological conditions accounting for the highest risk of role impairment among university students.

methodCross-sectional online survey of first-year students (60 universities, 10 countries) assessing role impairment due to emotional problems in previous 30 days with the 3-item emotional subscale of the VR-36. Cross-tabulations and Poisson regression examined associations between 12 psychopathological conditions (8 probable mental disorders and 4 SITB) and socio-demographics with "significant role impairment" ("most"/"all of the time" in 2+ VR-36 items). We used machine learning methods to predict probabilities (risk) of significant role impairment based on the 12 psychopathological conditions. Observed prevalence of significant role impairment was examined within and across the 20 population ventiles to assess risk concentration using sensitivity (SN) and positive predictive value (PPV).

results43,990 students responded to the survey (median age = 19, IQR = 18-23). 27.1 % had significant role impairment due to emotional problems and 65.8 % had at least one psychopathological condition. Students with one or more of these conditions were more likely to have significant impairment than those without (RR = 3.9; 95 %CI: 3.6-4.2). In multivariable analyses, probable Depression and Bipolar disorders were the strongest correlates of significant impairment. Most (69.6 %) of the observed significant role impairment occurred among the roughly 35 % of respondents with highest predicted risk (PPV = 53.2 %).

conclusionSignificant role impairment due to emotional problems is highly prevalent among university students. High risk of significant role impairment concentrates in one third of the students, those with several psychopathological conditions. Assessing these conditions should help identifying highest role impairment risk university students.

Indexed as

Mental DisordersSelf-Injurious BehaviorStudentsAdolescentAdultCross-Sectional StudiesFemaleHumansMalePrevalenceRisk FactorsSurveys and QuestionnairesUniversitiesYoung Adultmental disordersrisk concentrationrisk predictionrole impairmentself-injurious thoughts and behaviorstargeted interventionsuniversity students

Identifiers

PMID41371359
PMCPMC13108612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.