Evidence map›Paper›PMID 41371157›Full record

ReviewCurrent opinion in biotechnology2026

Mapping multipathology via spatial omic integration.

Ryan Palaganas, Dimitrios N Sidiropoulos, Meaghan Morris, Genevieve L Stein-O'Brien

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryan PalaganasDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dimitrios N SidiropoulosJohns Hopkins Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, MD, USA.
Meaghan MorrisKavli Neuroscience Discovery Institute, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Genevieve L Stein-O'BrienDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Johns Hopkins Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Kavli Neuroscience Discovery Institute, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Single Cell Training and Analysis Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: gsteinobrien@jhmi.edu.

Funding

Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI JUAN TRONCOSO · 2020 to 2026
$29.3M
Mapping the single cell state basis of metastasis in space and timeU01CA284090 · NCI · JOHNS HOPKINS UNIVERSITY · PI Andrew Josef Ewald · 2023 to 2026
$2.7M
Informing mechanistic rules of agent-based models with single-cell multi-omicsU24CA284156 · NCI · TRUSTEES OF INDIANA UNIVERSITY · PI Elana Fertig, Paul T Macklin · 2024 to 2026
$2.3M
Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space MethodsR00NS122085 · NINDS · JOHNS HOPKINS UNIVERSITY · PI STEIN-O'BRIEN, GENEVIEVE LAUREN · 2023 to 2025
$697k
Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space MethodsK99NS122085 · NINDS · JOHNS HOPKINS UNIVERSITY · PI STEIN-O'BRIEN, GENEVIEVE LAUREN · 2021 to 2022
$221k
NCI NIH HHS U01 CA284090NCI NIH HHS U24 CA284156NIA NIH HHS P30 AG066507NINDS NIH HHS K99 NS122085NINDS NIH HHS R00 NS122085
6 · The paper itself

Abstract

Neurodegenerative diseases (NDDs) are a global health crisis affecting 15% of the population, with projections indicating this burden will double within two decades. Despite having shared molecular hallmarks, co-occurring proteinopathies, predictable progression patterns, and overlapping genetic risk variants, what causes specific NDDs to manifest in a particular individual or even a particular cell type is unknown. Thus, systems biology approaches are necessary to decipher the molecular, cellular, and environmental interactions driving pathogenesis. Multi-omics spatial profiling preserves tissue architecture while mapping cellular phenotypes and molecular interactions at subcellular resolution. Systems biology integration of these modalities will facilitate the identification of underlying causes of neuronal vulnerability, protein aggregation mechanisms, and disease progression patterns, accelerating targeted therapeutic development across NDDs.

Indexed as

GenomicsNeurodegenerative DiseasesSystems BiologyAnimalsHumans

Identifiers

PMID41371157
PMCPMC12914700

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.