Evidence map›Paper›PMID 41370822›Full record

ReviewJournal of materials chemistry. B2026

Evaluating and improving biocompatibility of conductive polymers for cardiac tissue engineering.

Joel Aboagye, Marcella Edwards, Jing Ge, Yi Hong, Huaxiao Yang

Abstract readReview
In one paragraph

Review in Journal of materials chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joel AboagyeDepartment of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA. huaxiao.yang@unt.edu.
Marcella EdwardsDepartment of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA. huaxiao.yang@unt.edu.
Jing GeDepartment of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080, USA.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA. yihong@uta.edu.ORCID http://orcid.org/0000-0002-5846-2596
Huaxiao YangDepartment of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA. huaxiao.yang@unt.edu.

Funding

Elastic exosome-releasing conductive patches for heart repairR01HL175960 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI Ke Cheng, Yi Hong · 2025 to 2026
$1.4M
Assessing Tyrosine Kinase Inhibitors-induced Cardiotoxicity with an Organoid-AI SystemR56HL174856 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI YANG, HUAXIAO · 2024 to 2024
$547k
NOTCH signaling on the underdeveloped cardiac vascularization of hypoplastic left heart syndrome in the hiPSC-derived vascularized cardiac organoidsR15HD108720 · NICHD · UNIVERSITY OF NORTH TEXAS · PI YANG, HUAXIAO · 2022 to 2022
$438k
NHLBI NIH HHS R01 HL175960NHLBI NIH HHS R56 HL174856NICHD NIH HHS R15 HD108720
6 · The paper itself

Abstract

Conductive polymers (CPs) have gained increasing attention in cardiac tissue engineering (CTE) due to their ability to restore electrical conductivity, enhance cardiomyocyte (CM) function, and support tissue regeneration. Despite significant progress in the field, challenges related to variability in biocompatibility testing, including dopant-dependent cytotoxicity, poor reporting of biodegradability, unpredictable long-term stability, and regulatory uncertainty of CPs continue to hinder their applications. To address this, we reviewed the properties, applications, and biocompatibility of the three most studied CPs: polypyrrole (PPy), poly(3,4-ethylenedioxythiophene) (PEDOT), and polyaniline (PANI) in CTE, and contrast their advantages and safety challenges with inorganic electrodes and carbon-based materials. We critically assessed current methods for evaluating the biocompatibility of CPs, highlighting limitations in traditional

Indexed as

Biocompatible MaterialsPolymersTissue EngineeringAniline CompoundsAnimalsBridged Bicyclo Compounds, HeterocyclicElectric ConductivityHumansMaterials TestingMyocytes, CardiacPyrrolesTissue ScaffoldsAniline CompoundsBiocompatible MaterialsBridged Bicyclo Compounds, Heterocyclicpoly(3,4-ethylene dioxythiophene)polyanilinePolymerspolypyrrolePyrroles

Identifiers

PMID41370822
PMCPMC12831229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.