Evidence map›Paper›PMID 41370422›Full record

SynthesisJBRA assisted reproduction2025

Lead exposure is associated with increased lead bioaccumulation and a decline in semen quality: a systematic review and meta-analysis.

Victoria Ifeoluwa Adisa, Precious Jesutofunmi Ashonibare, Cecilia Adedeji Adegbola, Tunmise Maryanne Akhigbe, Oluwakemi Rebecca Kolawole, Isaac Ayomide Omole, Fabrael Batale Fidelis, Adetomiwa Ezekiel Adeogun, Rebecca Promise Oluwole, Bolaji Aderibigbe Akorede and 11 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in JBRA assisted reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Victoria Ifeoluwa AdisaDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Precious Jesutofunmi AshonibareDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Cecilia Adedeji AdegbolaDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Tunmise Maryanne AkhigbeReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Oluwakemi Rebecca KolawoleDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Isaac Ayomide OmoleDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Fabrael Batale FidelisReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Adetomiwa Ezekiel AdeogunDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Rebecca Promise OluwoleReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Bolaji Aderibigbe AkoredeReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Babatunde David OgunkolaReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Adebayo Oluwafemi AdekunleReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Suliat Adenike HassanReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Sulaiman Shuaibu MansurReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Sulaimon Bayonle AjeigbeReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Precious Adeoye OyedokunDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Victory Jesutoyosi AshonibareReproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.
Olayinka Emmanuel AdelowoDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Racheal Ibukun OyesetanDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Ayoola Abimbola OladipoDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
Roland Eghoghosoa AkhigbeDepartment of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis systematic review and meta-analysis aimed to assess the impact and associated mechanisms of lead on human semen quality.

methodsA systematic search was conducted from March 18th to April 30th, 2024, utilizing Google Scholar, PubMed, and Scopus, and applying the PECOS model to identify relevant studies.

resultsA total of seventeen studies fulfilled the inclusion criteria. The results of our analysis indicated that blood lead levels were markedly elevated in men exposed to lead compared to control subjects (SMD -7.06 [95% CI: -9.03, -5.08], p<0.00001), with analogous results observed for semen lead levels (SMD -3.42 [95% CI: -5.22, -1.62], p=0.0002). Lead exposure was linked to significant decreases in ejaculate volume (SMD 0.81 [95% CI: 0.16, 1.45], p=0.02), sperm count (SMD 2.10 [95% CI: 1.11, 3.09], p<0.0001), sperm concentration (SMD 0.77 [95% CI: 0.09, 1.44], p=0.03), and total motility (SMD 2.20 [95% CI: 1.28, 3.11], p<0.00001), as well as an increase in abnormal sperm morphology (SMD -3.29 [95% CI: -4.87, -1.71], p<0.0001). While reductions in testosterone levels and elevations in semen malondialdehyde were noted, these changes did not reach statistical significance.

conclusionsThis study demonstrates that lead exposure is associated with reduced sperm quality. The present findings highlight the urgent need for strategies to reduce lead exposure and emphasize the importance of further research into potential mitigating interventions.

Indexed as

Environmental ExposureLeadSemenSemen AnalysisHumansMaleSperm CountSperm MotilityLeadendocrine disruptorsheavy metalsleadmale infertilitysementestosterone

Identifiers

PMID41370422
PMCPMC12695014

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.