Evidence map›Paper›PMID 41370397›Full record

ReviewScience advances2025

Stereospecific cross-coupling reactions: Programmed assembly of chiral molecules by reaction of chiral reagents.

Hao Liang, Xieyang Zhang, James P Morken

Abstract readReview
In one paragraph

Review in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Iron-Catalyzed Dealkenylative Borylation of Alkenes via Ozonolysis.Journal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hao LiangDepartment of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.ORCID 0000-0002-0284-1888
Xieyang ZhangDepartment of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.ORCID 0009-0005-0972-208X
James P MorkenDepartment of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.ORCID 0000-0002-9123-9791

Funding

New Strategies in Catalytic Organic Synthesis with Organoboron ReagentsR35GM127140 · NIGMS · BOSTON COLLEGE · PI JAMES Patrick MORKEN · 2018 to 2026
$5.1M
Development of Catalytic Conjunctive Coupling ReactionsR01GM118641 · NIGMS · BOSTON COLLEGE · PI MORKEN, JAMES PATRICK · 2017 to 2018
$635k
NIGMS NIH HHS R01 GM118641NIGMS NIH HHS R35 GM127140
6 · The paper itself

Abstract

Long recognized as being a challenge in the arena of cross-coupling reactions, the formation of C-C bonds between saturated carbon centers has become simpler because of advances in catalyst design. However, when these processes involve the reaction of chiral carbon centers, the control of reaction stereochemistry remains a pressing concern. One still-emerging strategy for stereocontrol in cross-coupling relies on construction of configurationally defined reactants paired with catalysts that transform these substrates with high stereochemical fidelity. In this review, we survey chiral organometallic reagents that may be formed with enantiocontrol and examine advances in their cross-coupling.

Identifiers

PMID41370397
PMCPMC12693989

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.