Evidence map›Paper›PMID 41370370›Full record

ArticleScience advances2025

Evolutionarily convergent mechanism of formin regulation coordinates actin polymerization in apicomplexan parasites.

Pengge Qian, Yong Fu, Jianwei Zeng, Michael J Naldrett, Rui Zhang, L David Sibley

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pengge QianDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St Louis, MO, USA.ORCID 0000-0002-3751-5783
Yong FuDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St Louis, MO, USA.ORCID 0000-0002-3912-5869
Jianwei ZengDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6880-3366
Michael J NaldrettProteomics and Metabolomics Facility, Nebraska Center for Biotechnology, University of Nebraska-Lincoln, Lincoln, NE, USA.ORCID 0000-0002-6899-5652
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3159-9565
L David SibleyDepartment of Molecular Microbiology, Washington University in St. Louis, School of Medicine, St Louis, MO, USA.ORCID 0000-0001-7110-0285

Funding

Structure and Function of the Conoid in ToxoplasmaR01AI179885 · NIAID · WASHINGTON UNIVERSITY · PI L. David Sibley, Rui Zhang · 2024 to 2026
$2.2M
NIAID NIH HHS R01 AI179885
6 · The paper itself

Abstract

Apicomplexan parasites rely on actin-based motility for host cell invasion and for their dissemination. Although previous studies implicate formin 1 (FRM1) in governing this process in

Indexed as

ActinsApicomplexaEvolution, MolecularForminsMicrofilament ProteinsParasitesProtozoan ProteinsToxoplasmaHumansModels, MolecularPolymerizationProtein BindingActinsForminsMicrofilament ProteinsProtozoan Proteins

Identifiers

PMID41370370
PMCPMC12693976

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.