ArticleChemistry & biodiversity2026
Four New Alkaloid Heterodimers From Scolopendra subspinipes mutilans.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Three rare pyrazine-containing alkaloid heterodimers scosubspiloids A-C (1-3) and one new spiro-indole heterodimer scosubspiloid D (4), along with seven known alkaloids (5-11) were isolated from Scolopendra subspinipes mutilans. Spectroscopic methods and ECD calculations were used to identify their structures. Biologically, 1-3 could significantly inhibit the proliferation of MDA-MB-231 cells at 20 µM. The investigation provided experimental evidences to support the traditional use of S. subspinipes mutilans in treating cancer, and revealed new structure type compounds in the medicinal animal.
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