Evidence map›Paper›PMID 41370347›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1.

Shuya Wang, Tong Li, Matthew Naish, Russell Chuang, Evan K Lin, Christian Fonkalsrud, Yan He, Suhua Feng, Ian R Henderson, Steven E Jacobsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuya WangMolecular Biology Institute, University of California, Los Angeles, CA 90095.ORCID 0000-0001-9850-4634
Tong LiDepartment of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom.
Matthew NaishDepartment of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom.
Russell ChuangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Evan K LinDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Christian FonkalsrudDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Yan HeMolecular Biology Institute, University of California, Los Angeles, CA 90095.ORCID 0009-0001-1435-5860
Suhua FengMolecular Biology Institute, University of California, Los Angeles, CA 90095.
Ian R HendersonDepartment of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom.ORCID 0000-0001-5066-1489
Steven E JacobsenMolecular Biology Institute, University of California, Los Angeles, CA 90095.

Funding

HHMI (HHMI) HHMI
6 · The paper itself

Abstract

DNA methylation is a conserved epigenetic modification essential for maintaining genome stability. However, how methyltransferases maintain CG methylation within compact chromatin, including centromeres, remains unclear. In humans, CDCA7 is necessary for the inheritance of DNA methylation at juxta-centromeres. Mutations that impair its ability to bind chromatin result in Immunodeficiency, Centromeric Instability, and Facial Anomalies (ICF) syndrome, characterized by centromeric instability. To investigate whether CDCA7 function is conserved, we identified two

Indexed as

ArabidopsisArabidopsis ProteinsCentromereDNA MethylationHeterochromatinHistonesDNA (Cytosine-5-)-MethyltransferasesHumansMutationArabidopsis ProteinsDNA (Cytosine-5-)-MethyltransferasesHeterochromatinHistonesMET1 protein, ArabidopsiscentromereDNA methylationepigeneticsgenome stabilitylinker histone H1

Identifiers

PMID41370347
PMCPMC12718391

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.