ArticlePLoS neglected tropical diseases2025
Calcineurin regulates morphological development, stress responses and virulence in Fonsecaea monophora.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Correction: Calcineurin regulates morphological development, stress responses and virulence in Fonsecaea monophora.PLoS neglected tropical diseases · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Fonsecaea monophora is a major cause of chromoblastomycosis (CBM) in southern China. While calcineurin is known to be a virulence factor in several fungi, its role in F. monophora remains poorly understood. In this study, we characterized the function of calcineurin in F. monophora by examining mutants of the two calcineurin subunit genes (cnaA and cnaB). The mutants exhibited significant defects in conidiation, germination, morphogenesis (including the transformation into muriform cells), resistance to various stressors, and increased susceptibility to triazole drugs. Importantly, the mutants showed greater susceptibility to macrophage-mediated killing in vitro and reduced virulence in a mouse model. Interestingly, deletion of the potential transcription factor gene (crzA) did not produce similar phenotypic changes, suggesting that calcineurin regulates these processes maybe independently of crzA. Our findings advance the understanding of calcineurin's role in the morphology, antifungal resistance, and virulence of F. monophora. Given that the combination of itraconazole and tacrolimus has a synergistic effect on clinical strains, we propose that targeting calcineurin in combination with itraconazole may offer an effective therapeutic approach for CBM.
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