ArticleCell reports2025
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.
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Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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Who cites it
3 citing papers in PubMed.
- Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas: current understanding and perspectives on malignant progression.Journal of gastroenterology · 2026Review
- HNF4α controls growth, identity, and KRAS inhibitor response in invasive mucinous adenocarcinoma of the lung.The Journal of clinical investigation · 2026Article
- IL-6 as a central driver of immune evasion in PDAC: from IDO-mediated tolerance to multi-pathway immunosuppression.Frontiers in immunology · 2026Review
Corrections and comments
- Update of
Authors and funding
26 authors.
Vincent Quoc-Huy TrinhDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Institute for Research in Immunology and Cancer and the Centre de recherche du Centre hospitalier de l'Université de Montréal, University of Montreal, Montreal, QC, Canada.
Katherine E AnkenbauerDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Sabrina M TorbitDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Christopher P TarantoProgram in Cancer Biology, Vanderbilt University, Nashville, TN, USA.
Jiayue LiuDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Maelle BatardiereInstitute for Research in Immunology and Cancer and the Centre de recherche du Centre hospitalier de l'Université de Montréal, University of Montreal, Montreal, QC, Canada.
Bhoj KumarComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
H Carlo MaurerDepartment of Internal Medicine II, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, München, Germany.
Frank RevettaDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Zhengyi ChenEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN 37232, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA.
Angela R S KruseDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Audra M JuddDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Celina CopelandDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Jahg WongInstitute for Research in Immunology and Cancer and the Centre de recherche du Centre hospitalier de l'Université de Montréal, University of Montreal, Montreal, QC, Canada.
Olivia Ben-LevyDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Brenda JarvisDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Monica BrownDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN 37232, USA.
Jeffrey W BrownDivision of Gastroenterology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Koushik DasDivision of Gastroenterology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Yuki MakinoDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jeffrey M SpragginsDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Chemistry, Vanderbilt University, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ken S LauDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN 37232, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Parastoo AzadiComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Anirban MaitraDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Marcus C B TanDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Kathleen E DelGiornoDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University, Nashville, TN, USA; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Computational Systems Biology, Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Digestive Disease Research Center, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: kathleen.delgiorno@vanderbilt.edu.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEPHEN W. FESIK · 2019 to 2026
$19.6MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MClinical Validation Center for Early Detection of Pancreatic CancerU01CA200468 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANIRBAN MAITRA · 2016 to 2026
$11.0MTumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic CancerU54CA274371 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANIRBAN MAITRA · 2022 to 2026
$9.5MBIOCHEMICAL &CHEMICAL TRAINING FOR CANCER RESEARCHT32CA009582 · NCI · VANDERBILT UNIVERSITY · PI David K Cortez · 1987 to 2026
$8.8MVANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced GenomicsG20RR030956 · NCRR · VANDERBILT UNIVERSITY · PI PIETENPOL, JENNIFER A · 2010 to 2010
$8.7MTRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4MVanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human KidneyU54DK134302 · NIDDK · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M, SPRAGGINS, JEFFREY M · 2022 to 2025
$7.1MNCI NIH HHS P30 CA068485NCI NIH HHS P50 CA236733NCI NIH HHS R01 CA220236NCI NIH HHS T32 CA009582NCI NIH HHS U01 CA200468NCI NIH HHS U01 CA294527NCI NIH HHS U54 CA274371NCRR NIH HHS G20 RR030956NCRR NIH HHS UL1 RR024975NEI NIH HHS P30 EY008126NEI NIH HHS U54 EY032442NIAID NIH HHS R21 AI156236NIA NIH HHS R01 AG078803NIDDK NIH HHS K08 DK132496NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK103831NIDDK NIH HHS T32 DK007673NIDDK NIH HHS U01 DK133766NIDDK NIH HHS U54 DK134302NIGMS NIH HHS R24 GM137782NIGMS NIH HHS R35 GM142709
Abstract
Intraductal papillary mucinous neoplasms (IPMNs) are cystic lesions and bona fide precursors of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Although ∼90% of IPMNs are detected before PDAC forms, markers distinguishing benign from malignant disease are lacking, resulting in an abundance of unnecessary, invasive surgeries. Recent studies show that pancreatic precancer assumes a pyloric phenotype. To identify the regulators of this plasticity, cell lines, organoids, tumors from mouse models of IPMNs, and patient samples underwent multiplex immunostaining, RNA sequencing, glycosylation profiling, and computational analysis. These data revealed that GNAS
Indexed as
Adenocarcinoma, MucinousCarcinoma, Pancreatic DuctalChromograninsGTP-Binding Protein alpha Subunits, GsMutationPancreatic Intraductal NeoplasmsPancreatic NeoplasmsPolysaccharidesAnimalsCell Line, TumorHumansMetaplasiaMiceChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsPolysaccharidesCP: cancerCREB3L1glycansGNASintraductal papillary mucinous neoplasmpancreatic cancerpyloric metaplasiaSPDEF
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.