ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Genetic Association of FABP4 with Cardiovascular Events: A Mendelian Randomization Study.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
BackgroundThere is conflicting evidence of the correlation between fatty acid binding protein 4 (FABP4) and cardiovascular disease (CVD) in previous observational studies.ObjectiveThis study aims to explore the genetic causal association between FABP4 and adverse cardiovascular (CV) events.MethodsA two-sample bidirectional Mendelian randomization (MR) analysis was performed using summary statistics from GWAS. The primary method used for MR analysis was the inverse-variance weighted (IVW) method, complemented by MR-Egger, weighted median, and weighted mode methods to explore the causal association between FABP4 and adverse CV events. For sensitivity analysis assessing heterogeneity and pleiotropy, MR-Egger and MR-PRESSO were employed to address horizontal pleiotropy, while Cochran's Q test was used to assess heterogeneity between instrumental variables (IVs). The leave-one-out analysis was used to detect outliers.ResultsIVW suggested that FABP4 showed no genetic causal effect on stroke (OR = 1.01, 95% CI = 0.98-1.04,
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