ArticleAging clinical and experimental research2025
Osteosarcopenia, bone-muscle interactions, and frailty risk: A prospective cohort study of community-dwelling older adults.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Osteosarcopenia: More Than the Sum of Its Parts? A Community-Based Study Across Sarcopenia Definitions.Calcified tissue international · 2026Article
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6 authors.
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Abstract
backgroundOsteosarcopenia, defined as the co-existence of osteopenia/osteoporosis and sarcopenia, may influence frailty risk in older adults. However, the longitudinal association between osteosarcopenia or its components and frailty remain unclear. This study aimed to address this.
methodsData from a prospective cohort study of community-dwelling adults in Australia. Frailty was defined by the presence of ≥ 3 components based on Fried criteria: exhaustion, slow gait speed, low grip strength, unintentional weight loss, and low physical activity. Osteosarcopenia was defined by osteopenia/osteoporosis (WHO criteria) and sarcopenia (European Working Group on Sarcopenia in Older People [EWGSOP2] and Sarcopenia Definition and Outcome consortium [SDOC]). Multivariable logistic regression models evaluated the associations between osteosarcopenia, its components and frailty.
resultsOf 300 enrolled, 151 (mean age: 65.1years, 59.6%women) completed follow-up (median: 4.8 years). Among 143 non-frails at baseline, 13 (9.1%) transitioned to frailty. Osteosarcopenia (versus non-osteosarcopenia) was associated with frailty irrespective of the definition used: EWGSOP2: OR = 9.53, 95%CI 2.53-35.92; SDOC: OR = 9.19, 95%CI 2.19-38.56). Grip strength reduction by 1 kg (OR = 0.92, 95%CI 0.84-1.00) and gait speed reduction by 0.1 m/sec (OR = 0.67, 95%CI 0.53-0.85) were associated with 8% and 33% lower odds of frailty, respectively, whereas bone mineral density or lean mass was not. An interaction between bone-muscle function and frailty risk was observed (p < 0.011), whereby higher values of grip strength were associated with lower odds of frailty when bone density was lower.
conclusionIn this prospective cohort study, osteosarcopenia increased the risk of frailty. Our interaction analysis suggests therapies targeting bone density and grip strength may mitigate frailty.
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