Evidence map›Paper›PMID 41369878›Full record

ArticleJapanese journal of radiology2026

Sequential scans of

Shin Morooka, Yasutaka Fushimi, Sachi Okuchi, Akihiko Sakata, Takayuki Yamamoto, Satoshi Nakajima, Katsuhiko Mitsumoto, Koji Itagaki, Manabu Kubota, Atsushi Shima and 6 more

Abstract read
In one paragraph

Article in Japanese journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shin MorookaDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yasutaka FushimiDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. yfushimi@kuhp.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-1982-3168
Sachi OkuchiDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Akihiko SakataDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takayuki YamamotoDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Satoshi NakajimaDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Katsuhiko MitsumotoDepartment of Clinical Radiology Service, Kyoto University Hospital, Kyoto, Japan.
Koji ItagakiDepartment of Clinical Radiology Service, Kyoto University Hospital, Kyoto, Japan.
Manabu KubotaDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Atsushi ShimaDepartment of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sakiho UedaDepartment of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kazuya GotoDepartment of Regulation of Neurocognitive Disorders, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Akira KuzuyaDepartment of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takashi HanakawaDepartment of Integrated Neuroanatomy and Neuroimaging, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nobukatsu SawamotoDepartment of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yuji NakamotoDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Funding

Clinical Research Program from Nihon Medi-Physics Co., Ltd. Clinical Research Program from Nihon Medi-Physics Co., Ltd.Japan Society for the Promotion of Science JP23K24259Japan Society for the Promotion of Science JP25K02603the Parkinson's and Alzheimer's Disease Dimensional Neuroimaging Initiative (PADNI) the Parkinson's and Alzheimer's Disease Dimensional Neuroimaging Initiative (PADNI)
6 · The paper itself

Abstract

purposeWe aimed to compare visual and quantitative assessments between PET/CT at 90 min and sequential PET/MRI at approximately 120 min after injection of MATERIALS AND

methodsEighty-three participants underwent both PET/CT and sequential PET/MRI. Two nuclear medicine physicians performed visual interpretations. SUVr was calculated using four reference regions-pons, whole cerebellum, cerebellar gray matter (CGM), and whole cerebellum and brainstem-and compared between PET/CT and PET/MRI. Centiloid Scale was also compared between PET/CT and PET/MRI. Subgroup analyses were conducted based on Centiloid scale. Associations between scan interval, age, and amyloid burden were evaluated using stepwise regression. Cerebrospinal fluid (CSF) biomarkers were compared with imaging findings in 52 participants. Additionally, six participants underwent dynamic PET/MRI at 0, 60, 90, and 120 min post-injection.

resultsVisual interpretation showed high agreement between PET/CT and PET/MRI (κ = 0.97), and 98% concordance with CSF findings. SUVr and Centiloid scale demonstrated a strong intraclass correlation coefficient of 0.96-0.98. However, SUVr and Centiloid scale were significantly higher from PET/CT than from PET/MRI, except for SUVr using CGM. Age and Centiloid scale were significant predictors of modality differences. Scan interval was also significant when CGM was used as the reference region. Dynamic PET/MRI revealed time-dependent increases in Centiloid scale among amyloid-positive participants. High concordance in visual and quantitative assessments was seen for

Indexed as

AmyloidAniline CompoundsBenzothiazolesBrainMagnetic Resonance ImagingMultimodal ImagingPositron-Emission TomographyPositron Emission Tomography Computed TomographyAdultAgedAged, 80 and overAge FactorsFemaleHumansMaleMiddle AgedAmyloidAniline CompoundsBenzothiazolesflutemetamolRadiopharmaceuticals18F-flutemetamolAmyloidCentiloid scaleStandardized uptake value ratio

Identifiers

PMID41369878
PMCPMC13038638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.