Evidence map›Paper›PMID 41369781›Full record

ArticleMolecular biology reports2025

Association between the telomerase rs2736100_CC genotype and a lower risk of chronic hepatitis C in Chinese males.

Guanghui Cheng, Gongwei Yang, Xifeng Sun, Qian Xin, Yueze Li, Chen Zong, Feng Long, Shiliang Zhang

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Guanghui ChengFirst Clinical School of Medicine, Shandong University of Traditional Chinese Medicine, 16369 Jingshi Street, Jinan, 250014, China.
Gongwei YangShandong Public Health Clinical Center, Shandong University, 2999 Gangxingxi Street, Jinan, 250013, China.
Xifeng SunInstitute of Medical Sciences, The Second Qilu Hospital of Shandong University, 247 Beiyuan Street, Jinan, 250033, China.
Qian XinInstitute of Medical Sciences, The Second Qilu Hospital of Shandong University, 247 Beiyuan Street, Jinan, 250033, China.
Yueze LiCheeloo College of Medicine, Shandong University, No.44 West Wenhua Road, Jinan, 250012, China.
Chen ZongInstitute of Medical Sciences, The Second Qilu Hospital of Shandong University, 247 Beiyuan Street, Jinan, 250033, China.
Feng LongDepartment of Clinical Laboratory, The Second Qilu Hospital of Shandong University, 247 Beiyuan Street, Jinan, 250033, China. 202162019077@email.sdu.edu.cn.
Shiliang ZhangDepartment of Cardiology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, 16369 Jingshi Street, Jinan, 250014, China. zhangshiliangsd@163.com.

Funding

Natural Science Foundation of Shandong Province ZR2021QH118Natural Science Foundation of Shandong Province ZR2022QH265
6 · The paper itself

Abstract

objectivesHepatitis C virus (HCV) is a major global health burden. While, host genetic context was considered to influence its infection risk. Here we aimed to identify if polymorphisms in telomerase reverse transcriptase (TERT), a key player in aging including immune-senescence, belong to the context.

methodsThe study included a total 1166 case-control cohort with 502 Chinese HCV patients and 664 sex/age-matched healthy controls. Quantitative PCR was used to test TERT rs2736098 and rs2736100 genotyping and Leukocyte telomere length (LTL).

resultsThe rs2736100_AC/CC genotypes were significantly associated with lower risk of HCV infection compared to the AA genotype (OR 0.770, 95%CI 0.603-0.983, P = 0.036). Further analyses showed that association between the telomerase rs2736100_CC genotype and a lower risk of chronic hepatitis C in Chinese males (OR 0.579, 95%CI 0.362-0.924, P = 0.022). There was no difference in the rs2736098 variants between controls and HCV patients. LTL and age-adjusted LTL were shorter in HCV patients compared with healthy adults, shorter telomeres with susceptibility to chronic hepatitis C.

conclusionsThe TERT rs2736100_CC genotype is associated with a lower HCV risk in Chinese males. LTL is shorter in HCV patients compared with healthy adults, which indicates that HCV has affected telomere length. These findings may have implications in HCV infector pathogenesis and prevention.

Indexed as

Hepatitis C, ChronicTelomeraseAdultAgedCase-Control StudiesChinaEast Asian PeopleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHepacivirusHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsTelomeraseTERT protein, humanHepatitis c virus (HCV)Leukocyte telomere length (LTL)rs2736100Telomerase reverse transcriptase (TERT)

Identifiers

PMID41369781

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.