Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026
Kinetics and concentrations of circulating 25-hydroxyvitamin D using different vitamin D repletion regimens.
Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D repletion guidelines in Armenia were untested. Adults deficient in vitamin D received supplementation via low dose-high frequency, medium dose-medium frequency, or high dose-low frequency regimens. All achieved vitamin D sufficiency within 12 weeks. Providers may determine the replacement strategy based on patient variables.
objectivesVitamin D deficiency is common throughout the world. While guidelines for vitamin D replacement exist, they have not been tested in Armenia. This study aimed to investigate the efficacy of three administration regimens to replete vitamin D: low dose-high frequency, medium dose-medium frequency, high dose-low frequency. MATERIAL AND
methodsWe recruited community-dwelling adults in Yerevan, Armenia, who were found to be deficient in vitamin D. Participants were subsequently randomized to receive vitamin D via oral drops according to one of three arms: (A) 7000 IU daily for 12 weeks followed by 3500 IU daily for 24 weeks; (B) 50,000 IU weekly for 12 weeks followed by 25,000 IU weekly for 24 weeks; and (C) 100,000 IU every other week for 12 weeks, followed by 50,000 IU every other week for 24 weeks. After 36 weeks, all subjects received the same amount of vitamin D. Circulating levels of 25(OH)D were measured at baseline, and at weeks 4, 8, 12, 24, and 36.
resultsThe mean baseline 25(OH)D level of the 60 adults who participated in the study (average age 44.8, 80% female) was 19.4 ng/mL. All three arms showed statistically significant increases in 25(OH)D levels from baseline to 4 weeks, and again from 4 to 8 weeks, following which levels plateaued at the mid-40s ng/mL. At baseline, group A had a slightly higher mean 25(OH)D level than group B (21.0 vs 16.9 ng/mL, p-value 0.03) as well as at week 36 (47.7 vs 40.2 ng/mL, p-value 0.007); otherwise, there were no significant differences between the groups at any other time points.
conclusionThis study supports a recommendation that different dosing regimens of vitamin D replacement will reach similar desirable levels when steady state is reached at weeks 12 and 36, thus enabling healthcare providers an option to determine the most appropriate replacement strategy based on individual patient preference and other variables.
Indexed as
Identifiers
41369768What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.