Evidence map›Paper›PMID 41369732›Full record

ReviewMammalian genome : official journal of the International Mammalian Genome Society2025

A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution.

Hilke Ehlich, Andrew Blease, Reva Biju, Montse Gustems, Fei Song, Sabine Fessele, Marzia Massimi, Konstantinos Bozonelos, Vasileios Ntafis, Anniina E Hiltunen and 32 more

Abstract readReview
In one paragraph

Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Hilke EhlichINFRAFRONTIER ERIC, Neuherberg, Germany. hilke.ehlich@infrafrontier.eu.ORCID 0000-0002-9355-4832
Andrew BleaseMary Lyon Centre at MRC Harwell, Harwell Campus, Oxfordshire, UK.ORCID 0000-0001-5784-7016
Reva BijuMary Lyon Centre at MRC Harwell, Harwell Campus, Oxfordshire, UK.ORCID 0009-0000-0598-6436
Montse GustemsINFRAFRONTIER ERIC, Neuherberg, Germany.ORCID 0000-0003-4447-0031
Fei SongINFRAFRONTIER ERIC, Neuherberg, Germany.ORCID 0009-0007-2626-7925
Sabine FesseleINFRAFRONTIER ERIC, Neuherberg, Germany.ORCID 0000-0002-5399-3574
Marzia MassimiItalian National Research Council (Institute of Biochemistry and Cell Biology), European Mouse Mutant Archive-Infrafrontier. Monterotondo Scalo, Rome, Italy.ORCID 0000-0001-5052-1822
Konstantinos BozonelosInstitute for Fundamental Biomedical Research, Biomedical Sciences Research Centre "Alexander Fleming" , Vari, Greece.
Vasileios NtafisInstitute for Fundamental Biomedical Research, Biomedical Sciences Research Centre "Alexander Fleming" , Vari, Greece.ORCID 0000-0003-1271-1187
Anniina E HiltunenBiocenter Oulu, Transgenic and Tissue Phenotyping Core Facility, University of Oulu, Oulu, Finland.ORCID 0000-0003-4019-6960
Susan MarschallInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0001-5191-7060
Claudia StoegerInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID 0000-0001-8361-0274
Zuzana KhorshidiKCTT Transgenic Core Facility, Comparative Medicine, Karolinska Institutet, Stockholm, Sweden.
Abdelmalek ZiadiCNRS-TAAM, Typage et Archivage d'Animaux Modèles, Centre National de la Recherche Scientifique, PHENOMIN, Orléans, France.ORCID 0009-0005-5430-2121
Karine JambouCNRS-TAAM, Typage et Archivage d'Animaux Modèles, Centre National de la Recherche Scientifique, PHENOMIN, Orléans, France.ORCID 0009-0007-6256-2446
Arsenio ArmagnoItalian National Research Council (Institute of Biochemistry and Cell Biology), European Mouse Mutant Archive-Infrafrontier. Monterotondo Scalo, Rome, Italy.ORCID 0009-0001-5965-8646
Ferdinando ScavizziItalian National Research Council (Institute of Biochemistry and Cell Biology), European Mouse Mutant Archive-Infrafrontier. Monterotondo Scalo, Rome, Italy.ORCID 0000-0002-4483-6753
Marcello RaspaItalian National Research Council (Institute of Biochemistry and Cell Biology), European Mouse Mutant Archive-Infrafrontier. Monterotondo Scalo, Rome, Italy.ORCID 0000-0002-3437-2430
Julia FernandezDepartment of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.
María Jesús Del HierroDepartment of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.ORCID 0000-0001-8883-0671
Abdelkader AyadiCNRS, INSERM, CELPHEDIA, PHENOMIN-ICS, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Graffenstaden, France.ORCID 0000-0002-7446-9659
Joelle PensavalleCNRS, INSERM, CELPHEDIA, PHENOMIN-ICS, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Graffenstaden, France.
Géraldine PrevostCNRS, INSERM, CELPHEDIA, PHENOMIN-ICS, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Graffenstaden, France.
Lucie DufkováCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.ORCID 0009-0006-7674-426X
Michaela KrupkovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.ORCID 0000-0002-9371-2511
Petr NicklCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.ORCID 0000-0002-4289-0502
Paul KrimpenfortDivision of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Marieke van de VenMouse Clinic for Cancer and Aging, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0001-6779-9353
Jos JonkersDivision of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-9264-9792
Gema Valera VázquezINFRAFRONTIER ERIC, Neuherberg, Germany.ORCID 0000-0001-5411-7560
Michael RaessINFRAFRONTIER ERIC, Neuherberg, Germany.ORCID 0000-0002-8759-1186
Johannes BeckersGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0001-7874-3822
Anna MolesItalian National Research Council (Institute of Biochemistry and Cell Biology), European Mouse Mutant Archive-Infrafrontier. Monterotondo Scalo, Rome, Italy.ORCID 0000-0002-5805-5763
Maik DahlhoffDepartment of Biological Sciences and Pathobiology, Institute of in vivo and in vitro Models, University of Veterinary Medicine, Vienna, Austria.ORCID 0000-0001-9189-7631
Lluis MontoliuDepartment of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC), Madrid, Spain.ORCID 0000-0003-3941-1176
Yann HéraultCNRS, INSERM, CELPHEDIA, PHENOMIN-ICS, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Graffenstaden, France.ORCID 0000-0001-7049-6900
Reetta HinttalaBiocenter Oulu, Transgenic and Tissue Phenotyping Core Facility, University of Oulu, Oulu, Finland.ORCID 0000-0002-7642-4008
Dimitris L KontoyiannisInstitute for Fundamental Biomedical Research, Biomedical Sciences Research Centre "Alexander Fleming" , Vari, Greece.ORCID 0000-0003-4682-9490
Radislav SedlacekCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.ORCID 0000-0002-3352-392X
Martin Hrabě de AngelisGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-7898-2353
Auke A Boersma *Department of Biological Sciences and Pathobiology, Institute of in vivo and in vitro Models, University of Veterinary Medicine, Vienna, Austria. auke.boersma@vetmeduni.ac.at.ORCID 0000-0002-3066-2836
Rafaele Matteoni *Italian National Research Council (Institute of Biochemistry and Cell Biology), European Mouse Mutant Archive-Infrafrontier. Monterotondo Scalo, Rome, Italy.ORCID 0000-0002-0314-5948

Funding

Agence Nationale de la Recherche ANR-10-INBS-07 PHENOMINCSIC support for large European infrastructures INFRA23012Czech Academy of Sciences RVO 68378050European Commission 101131669IdEx Unistra ANR-10-IDEX-0002INBS PHENOMIN ANR-10-INBS-07Ministry of Education, Youth and Sports (MEYS) LM202303 , LM2018126Ministry of Education, Youth and Sports (MEYS) LM202303, LM2018126Ministry of Education, Youth and Sports (MEYS); European Structural and Investing Funds (ESIF) CZ.02.1.01/0.0/0.0/16_013/0001789UKRI Medical Research Council MC_UP_2201/2University of Oulu, Biocenter Finland, and Research Council of Finland 367712ΙnfrafrontierGR / Phenotypos MIS 5002135
6 · The paper itself

Abstract

Ensuring the quality and reproducibility of biological resources is essential for advancing biomedical research and upholding animal welfare standards. The European Mouse Mutant Archive (EMMA), part of the INFRAFRONTIER research infrastructure, plays a key role in this effort by cryopreserving scientifically validated mutant mouse and rat strains and making them accessible to the global scientific community. To further enhance its processes and promote transparency, INFRAFRONTIER/EMMA has developed a set of ten Quality Principles specifically tailored to the unique requirements of cryopreserved rodent mutant strains. These principles guide EMMA's workflows by providing a structured yet flexible quality framework across its distributed nodes. They encompass both general standards-such as adherence to the 3Rs (Replace, Reduce, Refine), staff competence, and continuous improvement-and more specific areas including scientific evaluation, data curation, and intellectual property rights. Each principle is presented with contextual background, defined requirements, practical recommendations, and key references. This initiative aims to strengthen the reliability, ethical integrity, and reproducibility of preclinical research resources.

Indexed as

CryopreservationDisease Models, AnimalAnimalsAnimal WelfareBiomedical ResearchMiceMutationRatsReproducibility of Results

Identifiers

PMID41369732
PMCPMC12696051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.