Lignin Nanoparticles from Coffee Grounds Enhance the Cytotoxicity of Coffee Grounds Lignin and Induce Apoptosis in Colorectal Cancer (CRC) Cell Lines.

Shiwen Liu, Xin Zhang, Jihui Wang, Xuan Chen, Xiaoqin Pan, Junqiu Zhang, Jingyu Xu, Weibin Bai

Abstract read

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Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Shiwen LiuDepartment of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou 510632, China.

Xin ZhangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.ORCID 0009-0004-1541-7658

Jihui WangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.

Xuan ChenSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.

Xiaoqin PanSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.

Junqiu ZhangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.

Jingyu XuCollege of Materials Science and Engineering, Qiqihar University, Qiqihar 161006, China.ORCID 0000-0002-6724-9623

Weibin BaiDepartment of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou 510632, China.

Funding

China Postdoctoral Science Foundation 2024M751129

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most common malignant tumor worldwide, with morbidity and mortality rates increasing annually. Consequently, the development of safe and effective natural anti-tumor drugs has become a critical research focus. Lignin, a polyphenolic polymer abundant in nature, possesses a unique chemical structure that imparts antioxidant, anti-inflammatory, and tumor cell-related bioactivities, demonstrating remarkable potential in the prevention and treatment of CRC. In this study, we investigated the anti-tumor cell effects of coffee grounds lignin nanoparticles (CLN), prepared using aqueous ethanol extraction from coffee waste, against three CRC cell lines (HCT116, HT29, SW620). The results indicated that CLN potently inhibited the proliferation of all three CRC cell lines mentioned above. This research supports the transformation of lignin from natural products into innovative anti-colorectal cancer agent, offering new insights for the development of novel therapeutic strategies characterized by low toxicity and high efficacy. As research advances and technology continues to innovate, lignin-based nanoparticles emerge as key natural products in CRC therapy, offering new hope for patients and paving the way for the application of natural products in cancer therapy.

Indexed as

coffee groundscolorectal cancerlignin nanoparticles

Identifiers

PMID41369431

DOI10.3390/nano15231754

PMCPMC12693052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.