Evidence map›Paper›PMID 41369414›Full record

ArticleCells2025

Regulation of CLK1 Isoform Expression by Alternative Splicing in Activated Human Monocytes Contributes to Activation-Associated TNF Production.

Maurice J H van Haaren, Alejandra Bodelón, Lyanne J P M Sijbers, Rianne Scholman, Lucas W Picavet, Jorg J A Calis, Sebastiaan J Vastert, Jorg van Loosdregt

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maurice J H van HaarenCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0009-0001-9184-0480
Alejandra BodelónCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0003-2361-8156
Lyanne J P M SijbersCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0009-0009-1015-164X
Rianne ScholmanCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Lucas W PicavetCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0009-0003-0638-720X
Jorg J A CalisCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Sebastiaan J VastertCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-4226-0949
Jorg van LoosdregtCenter for Translational Immunology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

Funding

ReumaNederland LLP10
6 · The paper itself

Abstract

Alternative splicing is a key regulator of immune regulation by enabling rapid and context-specific responses. However, the role of splicing regulators such as CDC-like kinase 1 (CLK1) in monocyte biology remains poorly defined. Here, we identify and characterize distinct CLK1-splice isoforms in human CD14

Indexed as

Alternative SplicingMonocytesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesTumor Necrosis Factor-alphaHumansLipopolysaccharidesProtein IsoformsClk dual-specificity kinasesLipopolysaccharidesProtein IsoformsProtein Serine-Threonine KinasesProtein-Tyrosine KinasesTumor Necrosis Factor-alphaalternative splicingCLK1long-read RNA-seqmonocytes

Identifiers

PMID41369414
PMCPMC12691408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.