Evidence map›Paper›PMID 41369413›Full record

ReviewCells2025

Understanding the Mechanisms Driving Fibrosis Following Cochlear Implantation-Lessons from Other Tissues.

Cecilia M Prêle, Kady J Braack, Marcus Atlas, Jafri Kuthubutheen, Tylah Miles, Wilhelmina H A M Mulders, Steven E Mutsaers

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cecilia M PrêleSchool of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA 6150, Australia.
Kady J BraackInstitute for Respiratory Health, The University of Western Australia, Nedlands, Perth, WA 6009, Australia.ORCID 0000-0003-1076-5843
Marcus AtlasEar Science Institute Australia, Nedlands, Perth, WA 6009, Australia.
Jafri KuthubutheenDivision of Surgery, Medical School, The University of Western Australia, Nedlands, Perth, WA 6009, Australia.
Tylah MilesInstitute for Respiratory Health, The University of Western Australia, Nedlands, Perth, WA 6009, Australia.
Wilhelmina H A M MuldersSchool of Human Sciences, The University of Western Australia, Crawley, Perth, WA 6009, Australia.ORCID 0000-0001-8721-7357
Steven E MutsaersInstitute for Respiratory Health, The University of Western Australia, Nedlands, Perth, WA 6009, Australia.ORCID 0000-0002-2615-8338

Funding

National Health and Medical Research Council 2011143
6 · The paper itself

Abstract

Cochlear implants are highly successful in restoring speech perception but variability in outcomes exists. Post-surgical fibrosis and neo-ossification are thought to play a significant role, being linked to increased impedance and loss of residual hearing and posing challenges for re-implantation. Hence, there is growing interest in pharmacological interventions to limit intracochlear fibrosis and neo-ossification. While current approaches focus on steroids, studies in other organs have identified many candidate drugs. However, selection is hindered by a limited understanding of the molecular and cellular mechanisms driving fibrosis after implantation. This review introduces potential drug candidates for cochlear implant-induced fibrosis, with many targeting core fibrotic pathways such as TGF-β/SMAD, PDGF, and Wnt/β-catenin or inhibiting pro-inflammatory signalling. By drawing on lessons from other tissues, this review identifies mechanisms and therapeutic approaches adaptable to the cochlea. Understanding fibrosis across organs will guide strategies to prevent or reverse cochlear fibrosis. Their translation requires careful evaluation of local delivery, minimal ototoxicity, and effects on the electrode-tissue interface.

Indexed as

CochleaCochlear ImplantationCochlear ImplantsAnimalsFibrosisHumansanti-fibroticcochlear implantfibrosisforeign body responseneo-ossificationscarring

Identifiers

PMID41369413
PMCPMC12691066

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.