Evidence map›Paper›PMID 41369403›Full record

ArticleCells2025

CFTR Modulator Response in Nasal Organoids Derived from People with Cystic Fibrosis.

Stefania Lo Cicero, Germana Castelli, Aurora Ceci, Anna Maria Cerio, Giovanna Blaconà, Mariarita Virgulti, Sara Allushi, Giovanni Sette, Francesca Spadaro, Felice Amato and 6 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stefania Lo CiceroDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Germana CastelliDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-3593-1230
Aurora CeciDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0009-0003-9018-2329
Anna Maria CerioDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Giovanna BlaconàDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-1955-820X
Mariarita VirgultiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Sara AllushiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Giovanni SetteDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Francesca SpadaroConfocal Microscopy Unit, Core Facilities, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-6610-350X
Felice AmatoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-0596-2933
Paola MelottiCystic Fibrosis Centre, Azienda Ospedaliera Universitaria Integrata Verona, 37126 Verona, Italy.ORCID 0000-0002-5276-1595
Claudio SorioDepartment of Medicine, Division of General Pathology, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-2739-4014
Giuseppe CiminoCystic Fibrosis Reference Center of Lazio Region, AOU Policlinico Umberto I, 00161 Rome, Italy.
Mauro BiffoniDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.
Marco LucarelliDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-5538-2494
Adriana EramoDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

Funding

European Union - NextGenerationEU through the Italian Ministry of University and Research under PNRR PNRR - M4C2-I1.3 Project PE_00000019 "HEAL ITALIA"Italian Cystic Fibrosis Foundation FFC 8/2020; FFC 8/2021Ministero dell'Università e della Ricerca - PRIN 2022 N.2022FRSS2H, B53D23020270006Pasteur Institute Cenci Bolognetti Foundation project 2022-2023 Anna Tramontano (call 2020)
6 · The paper itself

Abstract

Despite the progressive extension of

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorNasal MucosaOrganoidsAminophenolsBenzodioxolesGenotypeHumansIndolesMutationQuinolonesAminophenolsBenzodioxolesCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorIndolesivacaftorQuinolonestezacaftorairway organoidsairway stem cellsCFTR pathogenic variantscystic fibrosisdisease modelingtargeted therapy

Identifiers

PMID41369403
PMCPMC12691081

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.