Evidence map›Paper›PMID 41369345›Full record

ArticleCells2025

Negative Allosteric Modulation of Agonist-Induced M

Laura C Carrera Páez, Sabrina P Beltrame, Sergio R Auger, Ahmad H Sabra, Claudio R Bilder, Isabel M Irurzun, Claudia I Waldner, Juan C Goin

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura C Carrera PáezLaboratorio de Farmacología Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA) y II Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.ORCID 0009-0003-4238-732X
Sabrina P BeltrameLaboratorio de Farmacología Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA) y II Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.ORCID 0009-0005-6846-2871
Sergio R AugerHospital Donación Francisco Santojanni, Buenos Aires C1408INH, Argentina.ORCID 0009-0006-1135-3233
Ahmad H SabraHospital Donación Francisco Santojanni, Buenos Aires C1408INH, Argentina.ORCID 0009-0002-8493-4857
Claudio R BilderLaboratorio de Neurogastroenterología, Fundación Favaloro-Hospital Universitario, Buenos Aires C1093AAS, Argentina.ORCID 0009-0002-7898-2908
Isabel M IrurzunCentro de Simulación Computacional para Aplicaciones Tecnológicas (CSC-CONICET), Buenos Aires C1425FQD, Argentina.ORCID 0000-0001-5357-2107
Claudia I WaldnerLaboratorio de Inmunidad Celular y Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.ORCID 0000-0002-9070-4858
Juan C GoinLaboratorio de Farmacología Molecular, Centro de Estudios Farmacológicos y Botánicos (CEFYBO-CONICET-UBA) y II Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121ABG, Argentina.ORCID 0000-0002-2184-1111

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas PIP CONICET 2023-2025 # 0027Consejo Nacional de Investigaciones Científicas y Técnicas PIP CONICET 2023-2025 # 0433
6 · The paper itself

Abstract

Inhibition of agonist-induced M

Indexed as

Autoantibodiesbeta-ArrestinsChagas DiseaseReceptor, Muscarinic M2Allosteric RegulationAntibody SpecificityChronic DiseaseEpitopesHEK293 CellsHumansLigandsProtein BindingAutoantibodiesbeta-ArrestinsEpitopesLigandsReceptor, Muscarinic M2autoimmunitybiased ligandBRETdysautonomiaheart diseaseneglected tropical diseaseneurotransmitter receptorpathophysiologysignal transductionTrypanosoma cruzi

Identifiers

PMID41369345
PMCPMC12690989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.