Evidence map›Paper›PMID 41369341›Full record

ArticleCells2025

Targeting Astrocytic Connexin 43 Mitigates Glutamate-Driven Motor Neuron Stress in Late-Onset Spinal Muscular Atrophy.

Schahin Salmanian, Linda-Isabell Schmitt, Kai Christine Liebig, Stefanie Hezel, Andreas Roos, Ulrike Schara-Schmidt, Christoph Kleinschnitz, Markus Leo, Tim Hagenacker

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Schahin SalmanianDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.
Linda-Isabell SchmittDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.
Kai Christine LiebigDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.ORCID 0009-0009-5696-3459
Stefanie HezelDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.
Andreas RoosDepartment of Pediatric Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.ORCID 0000-0003-2833-0928
Ulrike Schara-SchmidtDepartment of Pediatric Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.
Christoph KleinschnitzDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.ORCID 0000-0002-1650-8875
Markus LeoDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.ORCID 0000-0002-3449-9829
Tim HagenackerDepartment of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, 45147 Essen, Germany.ORCID 0000-0002-3631-3450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5q-associated Spinal Muscular Atrophy (SMA) is a hereditary neuromuscular disorder caused by mutations in the

Indexed as

AstrocytesConnexin 43Glutamic AcidMotor NeuronsMuscular Atrophy, SpinalAnimalsCalciumDisease Models, AnimalGap JunctionsHumansMiceSurvival of Motor Neuron 1 ProteinCalciumConnexin 43Glutamic AcidSurvival of Motor Neuron 1 Proteincalcium ionexcitotoxicityGap27gap junctioninduced pluripotent stem cellsmotor neuronmouse model

Identifiers

PMID41369341
PMCPMC12691144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.