ArticleGut microbes2025
Longitudinal analysis of fecal tryptophan metabolites and microbiome composition in very preterm infants: impact of birth mode and feeding type.
Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Tryptophan-Kynurenine Pathway Metabolites in Women Undergoing Caesarean Delivery.Life (Basel, Switzerland) · 2026Article
- Mechanisms by which tryptophan metabolites enhance intestinal barrier function to prevent necrotizing enterocolitis in preterm infants.Frontiers in immunology · 2026Review
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Authors and funding
13 authors.
Funding
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Abstract
Preterm birth is associated with increased morbidity and mortality due to factors such as prolonged NICU stays, antibiotic treatments, and immature gastrointestinal and immune systems. These factors disrupt early gut microbial colonization, yet the functional metabolic implications remain understudied. Emerging evidence highlights the role of tryptophan metabolism as a mediator of host-microbiome interactions, critical for intestinal homeostasis and immune regulation. However, its dynamics and relationship with microbial composition in preterm infants are poorly understood. In this study, we longitudinally characterized the microbiome and 21 fecal bioactive tryptophan metabolites during the first month of life in 53 very preterm infants <30 weeks of gestation. Targeted tryptophan metabolomics and 16S rDNA sequencing revealed that cesarean delivery and supplemented feeding was associated with elevated host-derived kynurenine metabolites. Breastfeeding promoted beneficial microbiome colonization, including increased
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