Evidence map›Paper›PMID 41369228›Full record

ArticleHLA2025

Harnessing HLA Divergence for Improved Donor Selection in Haploidentical Haematopoietic Stem Cell Transplantation.

Debora Jorge Cordeiro, Juliette Villemonteix, Alienor Xhaard, Ophélie Ferrary, William Dartois, Bruno A Lima, Laurie Toullec, Regis Peffault de Latour, Sophie Caillat-Zucman, Vincent Allain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HLA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Debora Jorge CordeiroLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.ORCID 0000-0002-9678-4131
Juliette VillemonteixLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.ORCID 0000-0002-6601-7820
Alienor XhaardService d'Hématologie-Greffe, Hôpital Saint-Louis, AP-HP, Paris, France.ORCID 0000-0002-4449-989X
Ophélie FerraryLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
William DartoisLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
Bruno A LimaOficina de Biostatistica, Ermesinde, Portugal.ORCID 0000-0001-9090-4457
Laurie ToullecLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.
Regis Peffault de LatourService d'Hématologie-Greffe, Hôpital Saint-Louis, AP-HP, Paris, France.ORCID 0000-0001-6222-4753
Sophie Caillat-ZucmanLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.ORCID 0000-0002-4535-3550
Vincent AllainLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, Paris, France.ORCID 0000-0002-1068-7892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Haploidentical haematopoietic stem cell transplantation (haplo-HSCT) with post-transplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis is commonly used in patients without a fully matched donor. HLA evolutionary divergence (HED), a surrogate for the diversity of the immunopeptidome, can predict HLA-matched HSCT outcomes. Because of the peculiarities of HED measurement in haplo-HSCT, we designed a new HED

Indexed as

Donor SelectionGraft vs Host DiseaseHematologic NeoplasmsHematopoietic Stem Cell TransplantationHLA AntigensTransplantation, HaploidenticalAdolescentAdultAgedCyclophosphamideFemaleHaplotypesHistocompatibility TestingHumansMaleMiddle AgedCyclophosphamideHLA Antigenshaematopoietic stem cell transplantation (HSCT)haploidentical donorHLA evolutionary divergence (HED)immunopeptidome

Identifiers

PMID41369228
PMCPMC12691898

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.