Evidence map›Paper›PMID 41369170›Full record

ArticleApplied and environmental microbiology2026

Combined computational, rational, and empirical design of boiling-resistant keratinase.

Yong Yang, Yuewen Luo, Yidi Ding, Yitong Yao, Jie Liu, Zinan Xu, Yu Li, Huai Li, Fei Gan, Xiao-Feng Tang and 1 more

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Reengineering a thermostable keratinase past the boiling point.Applied and environmental microbiology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yong YangHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Yuewen LuoHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Yidi DingHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Yitong YaoState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
Jie LiuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Zinan XuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Yu LiHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Huai LiHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.
Fei GanHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0000-0003-1670-5251
Xiao-Feng TangHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0000-0003-4513-0389
Bing TangHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China.ORCID 0000-0002-6200-3720

Funding

National Natural Science Foundation of China 31770072National Natural Science Foundation of China 32470037
6 · The paper itself

Abstract

Engineering of highly thermostable keratinase is of great theoretical interest in understanding protein stability mechanisms and practical significance for processing keratinous wastes such as feathers and wool. The thermostable subtilisin-like protease C2 is the major keratinase secreted by

Indexed as

Bacterial ProteinsPeptide HydrolasesThermoactinomycesEnzyme StabilityHot TemperatureMolecular Dynamics SimulationPoint MutationProtein EngineeringBacterial ProteinskeratinasePeptide Hydrolasescomputational designkeratinaserational designsubtilasethermophilethermostability

Identifiers

PMID41369170
PMCPMC12838322

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.