ReviewAnnals of medicine2025
Exploring the ubiquitination regulatory network: opening new perspectives for rheumatoid arthritis therapy.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Endoplasmic Reticulum Stress as a Stage-Dependent Regulatory Hub in Rheumatoid Arthritis.Journal of inflammation research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a complex autoimmune disorder characterized by chronic systemic inflammation, primarily affecting the joints and synovium, but also involving multiple extra-articular tissues. This persistent inflammation contributes to progressive joint damage and the development of various systemic comorbidities. Despite significant advances in RA research, the underlying pathogenic mechanisms remain incompletely elucidated. Ubiquitination, a critical post-translational modification, regulates protein stability, localization, and function, and is essential in numerous biological processes, including cell signaling, immune regulation, and inflammatory responses. Emerging evidence highlights the pivotal role of ubiquitination in the pathogenesis of RA. This review provides a comprehensive overview of recent advances in the study of ubiquitination in RA, delineates its mechanistic contributions to disease development, and evaluates the therapeutic potential of targeting ubiquitination pathways. By offering new insights into RA pathophysiology, this review lays a theoretical and experimental foundation for the development of more effective, targeted therapeutic strategies, potentially opening new avenues for RA treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.