SynthesisColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2025
Management of anastomotic leak after elective anterior resection for rectal cancer: A systematic review and pooled analysis.
Synthesis in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Management of anastomotic leak after elective anterior resection for rectal cancer: A systematic review and pooled analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Early Post-Operative Diagnosis of Anastomotic Leak by Local Electrophysiological Parameters: Multicenter Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- Prevention, Recognition, and Management of Anastomotic Leakage and Pelvic Sepsis After Rectal Cancer Surgery: A Structured Narrative Review.Journal of clinical medicine · 2026Review
- Management of anastomotic leak following restorative rectal cancer resection-a multi-centre retrospective audit in Ireland.Irish journal of medical science · 2026Article
- Indocyanine green fluorescence angiography in laparoscopic sigmoid and rectal cancer surgery: no reduction in anastomotic leakage but a lower incidence of anastomotic strictures. A prospective single-center study.Frontiers in surgery · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnastomotic leak (AL) following rectal cancer resection significantly increases the clinical care, risks morbidity and mortality and impairs oncological outcomes. AL management is not standardised. This systematic review and pooled analysis evaluated the comparative efficacy of the various reported strategies.
methodAfter protocol generation with AMSTAR2, a systematic search was conducted in EMBASE, PubMed and SCOPUS. Primary and secondary outcome measures were pooled using the DerSimonian-Laird method with 95% confidence intervals, I
resultsSixteen studies published between 2010 and 2024 comprising 7236 patients, 850 with AL, met eligibility criteria albeit with significant heterogeneity (I
conclusionDrainage techniques demonstrate high success with low mortality and further intervention rate albeit with lengthened hospital stay. Surgical approaches also achieve success although mortality and long-term stoma rates are higher. Future studies need a core outcome set.
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Registered trials
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