ArticleJournal of magnetic resonance imaging : JMRI2026
Mapping Intracellular Volume Fraction With Susceptibility Source Decomposition as a Marker for Tissue Cellularity.
Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- When little brain goes to school: Impact of pedagogy on cerebellar peduncles' development.Developmental cognitive neuroscience · 2026Article
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8 authors.
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Abstract
backgroundPathophysiological changes affect tissue cell composition and density. For example, neurodegenerative disorders and brain tumors are associated with cell loss and abnormal accumulation, respectively. In these scenarios, if monitored and tracked, tissue cellularity might be used to inform clinical diagnosis and management. PURPOSE: To propose and evaluate a new marker of tissue cellularity, called susceptibility-Derived Cellularity Index (χDCI), that would be readily available for clinical applications with fast acquisition and at high resolution. STUDY TYPE: Retrospective study. POPULATION/SUBJECTS: 24 healthy subjects (7/17 M/F, 70 ± 11 years) and 21 patients with IDH-wild type glioblastoma (16/5 M/F, 65 ± 8 years). FIELD STRENGTH/SEQUENCE: 3 T MRI sequences including 3D T1w pre- and post-contrast agent injection, 3D T2w, 3D FLAIR, 3D multi-echo gradient recalled echo, 2D diffusion weighted imaging. ASSESSMENT: χDCI was computed based on parameters estimated with DECOMPOSE-QSM. The Neurite Density Index (NDI) was estimated with the NODDI model. T1w images were used for region of interest (ROIs) segmentations with FreeSurfer (i.e., cortical gray matter, white matter, thalamus, caudate, putamen, pallidum, hippocampus and amygdala). For the patients with glioblastoma, regions of contrast enhancement, necrosis, and edema were also included in the analysis. STATISTICAL TESTS: Pearson's correlation analysis between mean χDCI and NDI values in the ROIs was carried out separately for the two cohorts of participants (significance level = 0.05, after correction for multiple comparisons).
resultsSignificant correlations were observed between χDCI and NDI in white matter (r = 0.56) and putamen (r = 0.69) for the healthy participants. Significant positive correlations were also found in white matter (r = 0.6), pallidum (r = 0.48), putamen (r = 0.79), thalamus (r = 0.64) and edema (r = 0.69) for the patient cohort. DATA
conclusionχDCI is proposed as a marker of tissue cellularity. The significant associations between χDCI and NDI in several regions investigated in the present study support the potential of χDCI as a proxy of intracellular volume fraction. LEVEL OF EVIDENCE: 3: TECHNICAL EFFICACY: Stage 1.
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