Evidence map›Paper›PMID 41368627›Full record

ArticleFrontiers in immunology2025

Exuberant long noncoding RNA expression may sculpt Igh locus topology.

Ellen B Drake, Sarah Naiyer, Xinyan Qu, Khalid Bhat, Hammad Farooq, Mark Maienschein-Cline, Jie Liang, Amy L Kenter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ellen B DrakeDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, United States.
Sarah NaiyerDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, United States.
Xinyan QuDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, United States.
Khalid BhatDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, United States.
Hammad FarooqCenter for Bioinformatics and Quantitative Biology, and Department of Biomedical Engineering, University of Illinois Colleges of Engineering and Medicine, Chicago, IL, United States.
Mark Maienschein-ClineResearch Informatics Core, Research Resources Center, University of Illinois, Chicago, IL, United States.
Jie LiangCenter for Bioinformatics and Quantitative Biology, and Department of Biomedical Engineering, University of Illinois Colleges of Engineering and Medicine, Chicago, IL, United States.
Amy L KenterDepartment of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, United States.

Funding

Impact of novel enhancers on Igh repertoire diversityR01AI177507 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KENTER, AMY L · 2023 to 2025
$2.4M
NIAID NIH HHS R01 AI177507
6 · The paper itself

Abstract

Diverse Igh repertoires require successful V(D)J recombination allowing B cell receptor expression and Ig secretion for humoral immune responses. Igh locus contraction has been implicated in generating spatial proximity between distal V

Indexed as

Immunoglobulin Heavy ChainsRNA, Long NoncodingV(D)J RecombinationAnimalsB-LymphocytesChromatinGene Expression RegulationGenetic LociMiceChromatinImmunoglobulin Heavy ChainsRNA, Long Noncodingchromatin foldingIgH locuslong non-coding RNAprogenitor B cellsV(D)J recombination

Identifiers

PMID41368627
PMCPMC12682764

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.