ArticleInternational journal of genomics2025
Transcriptomic Analysis of Gingival Tissues: Insights Into Gene Expression Profiles.
Article in International journal of genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Transcriptomic Analysis of Gingival Tissues: Insights Into Gene Expression Profiles.International journal of genomics · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Objectives: The aim of this study was to understand the transcriptome and molecular pathways that drive unique functional characteristics of human gingiva. Materials and Methods: Gene expression data were obtained from the NCBI GEO database, including GSE38617 (connective tissue [CT]) and GSE7224 (gingival epithelium [GE]). Raw data were preprocessed and filtered for healthy samples. Differential gene expression analysis was performed using the limma package in R, with a significance cutoff of log Results: The analysis highlighted 11,096 DEGs between the dissected tissues. In CT, 7564 genes were upregulated in extracellular matrix (ECM) organization, collagen synthesis, and immunomodulation. GE had a total of 3532 upregulated genes enriched in epithelial barrier integrity, antimicrobial defense, and keratinocyte differentiation. These patterns were confirmed using key markers (CT: COL1A1 and COL3A1 and GE: DEFB1 and KRT10). In CT, pathway enrichment showed PI3K-Akt signaling and ECM-receptor interaction, whereas GE was characterized by tight junctions and the IL-17 signaling pathway. Conclusion: The differences in transcriptional landscapes of CT and GE illustrate specialized functions of each tissue type in maintaining periodontal health. Whereas CT focuses on ECM preservation and its immunomodulatory role, GE emphasizes antimicrobial defense and barrier function.
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