ReviewJournal of research in pharmacy practice
A Systematic Review of the Efficacy and Safety of Sirolimus (Rapamycin) in the Management of Infantile Hemangioma.
Review in Journal of research in pharmacy practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-Analysis of the Efficacy and Safety of Propranolol Versus Other Drugs in the Treatment of Infantile Hemangioma.Journal of cosmetic dermatology · 2026Pooled it
- Sirolimus for the treatment of vascular tumors and malformations in children: A 10-year single-institution retrospective study.World journal of clinical pediatrics · 2026Article
- Targeted Therapies in Infantile Hemangiomas and Vascular Malformations: From β-Blockers to PI3K/AKT/mTOR Inhibitors.Journal of cellular and molecular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The use of rapamycin (sirolimus) in the treatment of infantile hemangioma (IH) is a persistent challenge in dermatology. We aim to systematically review the efficacy and safety of rapamycin for IH treatment. Methods: We systematically searched PubMed, Web of Science, and Scopus for relevant English papers up to December 2024. After screening the full texts, eight studies met the inclusion criteria. The quality of the included articles was assessed using the Joanna Briggs Institute checklist. Detailed data about the effectiveness and safety of rapamycin in IH were collected. Findings: A total of 8 articles published between 2013 and 2021 were included, with 8 cases. The ages of the participants ranged from 3 weeks to 10 years. The most common dose of rapamycin used in these papers was 0.8 mg/m2 twice daily, with a range of 0.1 mg/m2 to 2 mg/m2 daily. Most patients had a response to rapamycin therapy (five out of eight patients). Two cases reported gastrointestinal adverse effects, whereas one developed severe, fatal hypoglycemia after angiography, which the authors considered the role that rapamycin in causing this complication to be unlikely. Conclusion: Rapamycin can be a safe and efficient medication in the treatment of IH. Combination therapy, especially in patients resistant to treatment for IH, is a preferred choice for IH treatment and reduces the side effects of propranolol. It is also preferred for the treatment of lesions in the mucosal areas and near important organs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.