ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2025
Initial Aspartate Aminotransferase-to-platelet Ratio Index is Associated with Sepsis-associated Liver Dysfunction in Adult Patients with Sepsis: A Retrospective Cohort Study.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Admission APRI and Early Mortality in ICU Patients with Sepsis: A Retrospective Cohort Study.Microorganisms · 2026Article
- Aminotransferase-to-platelet Ratio Index for Sepsis-associated Liver Dysfunction: Promising Triage Signal but Phenotype Confounding and Implementation Calibration must be Intensive Care Unit Ready.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Interpretable machine learning models for predicting New-onset acute organ injury within 48 hours of admission in patients with community-acquired acute cholangitis.Frontiers in medicine · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Aims and background: Sepsis-associated liver dysfunction (SALD) represents a prevalent and critical complication frequently observed in patients with sepsis. The association between the initial aspartate aminotransferase (AST)-to-platelet (PLT) ratio index (APRI) and SALD is unclear in adult patients diagnosed with sepsis. Patients and methods: We retrospectively analyzed data from the Medical Information Mart for Intensive Care-IV database. Sepsis-associated liver dysfunction was defined as an elevated serum aminotransaminase (>800 IU/L) or total bilirubin (>2 mg/dL) level. Multivariate and smoothing curve analyses were performed to investigate the relationship between the APRI [APRI = (AST (IU/L)/upper limits of normal)/PLT (k/uL)×100] and SALD. Subgroup analysis was additionally conducted to assess the robustness of the finding. Receiver operating characteristic (ROC) curve was performed to evaluate the discriminatory ability of SALD. External validation was performed using our own dataset. Results: Overall, 6,334 sepsis patients (SALD, Conclusion: A high initial APRI was linked to an elevated risk of developing SALD in adult patients with sepsis, as shown by the non-linear dose-dependent relationship. Clinical significance: Initial APRI is an easy and accessible tool that can be adopted for timely detection of the risk of SALD and prompt initiation of interventions for adult patients with sepsis. How to cite this article: Zhang B, Li X, Qin Z, Dong D, Yu W. Initial Aspartate Aminotransferase-to-platelet Ratio Index is Associated with Sepsis-associated Liver Dysfunction in Adult Patients with Sepsis: A Retrospective Cohort Study. Indian J Crit Care Med 2025;29(11):916-924.
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