ReviewIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2025
Aviptadil Therapy in Acute Respiratory Distress Syndrome Patients: A Systematic Review and Meta-analysis.
Review in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Aviptadil in Acute Respiratory Distress Syndrome-Promise or Mirage?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim and background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition with a high mortality rate despite advances in supportive care. Aviptadil, a synthetic analogue of vasoactive intestinal peptide (VIP), exhibits anti-inflammatory potential and cytoprotective effects that may improve pulmonary function. However, its role in improving survival among ARDS patients remains uncertain. This systematic review and meta-analysis aimed to evaluate the effectiveness of aviptadil in improving survival and oxygenation outcomes in ARDS. Methodology: A comprehensive search was conducted across six databases-PubMed, Scopus, Embase, Google Scholar, Cochrane Library, and Web of Science-up to October 2025. Two investigators independently screened eligible studies. Descriptive synthesis and meta-analysis were performed using a random-effects model. The risk of bias (RoB) was assessed with the RoB 2 tool for randomized controlled trials (RCTs) and the Joanna Briggs Institute (JBI) tool for case series. Results: The systematic review included nine studies (two RCTs and seven case series) with a total of 665 patients, 361 of whom received aviptadil. Meta-analysis of the two RCTs yielded a pooled prevalence of survival of 0.71 [95% confidence interval (CI): 0.53-0.87]. The survival odds ratio (OR) comparing aviptadil to placebo was 1.01 (95% CI: 0.72-1.42, Conclusion: Aviptadil may have a physiological role in improving oxygenation and reducing inflammation in ARDS; however, current evidence does not indicate a significant survival benefit. Larger, well-designed RCTs are needed to clarify its therapeutic potential. How to cite this article: Udupa AA, Todur P, Chaudhuri S, Gupta N, Bhat VR, Nagendra D,
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