ArticleFrontiers in neurology2025
White matter tracts involved in complex regional pain syndrome after subcortical stroke.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Post-stroke complex regional pain syndrome (CRPS) is a challenging complication that impairs recovery during stroke rehabilitation, particularly during the subacute phase. Despite its clinical significance, the neural substrates underlying post-stroke CRPS, specifically following subcortical stroke, remain unclear. This retrospective observational study included 40 patients with first-ever subcortical stroke diagnosed with CRPS via a three-phase bone scan, and 40 propensity score-matched controls without CRPS. White matter tract involvement was analyzed using atlas-based lesion mapping and voxel-based lesion overlap analysis in patients with available clinical scores and imaging findings (magnetic resonance imaging or computed tomography). Between-group comparisons of white matter tract involvement were conducted with false discovery rate (FDR) correction. Clinical characteristics were similar between groups, except for fewer CRPS patients with a shoulder flexor manual muscle test score ≥3. Lesion overlap with the cingulum in the cingulate gyrus was significantly greater in the CRPS group (
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