ArticleFood science & nutrition2025
Sulforaphene Mitigates Periodontitis by NRF2-Dependent Regulation of
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sulforaphene Mitigates Periodontitis by NRF2-Dependent Regulation ofFood science & nutrition · 2025Article
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13 authors.
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Abstract
Periodontitis is a prevalent chronic inflammatory disease closely associated with various systemic disorders. Conventional therapies, including mechanical debridement and antibiotics, are often insufficient to fully resolve inflammation or restore bone homeostasis. Sulforaphene (LFS) is abundant in radish seed oil and Lai Fu-zi, a traditional Chinese herbal medicine and has been recognized for its anti-inflammatory potential. Here, we show that LFS markedly attenuates the secretion of pro-inflammatory cytokines (IL-1β, IL-6, and IL-8) from human gingival fibroblasts and inhibits osteoclast differentiation even under IL-1β-induced inflammatory conditions, without compromising the osteogenic capacity of periodontal ligament cells (PDLC). Mechanistically, LFS activates the NRF2 pathway and its protective effect against alveolar bone loss was evident in
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