SynthesisFrontiers in medicine2025
Impact of frailty on postoperative complications in older adults after hip fracture: a systematic review of observational studies.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of multidimensional biomarkers of immune, nutritional, inflammatory, and metabolic status with postoperative outcomes in older hip fracture patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies.Frontiers in medicine · 2026Pooled it
- Aggregation-Sensitive Mortality Associations and Firth Penalized Logistic Regression After Hip Fracture Surgery: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Factors associated with selection of total hip arthroplasty versus hemiarthroplasty for femoral neck fracture in older adults: a nationwide analysis of 99,084 cases.Archives of orthopaedic and trauma surgery · 2026Article
- Thirty-Day Mortality After Hip Fracture Surgery: Association with In-Hospital Adverse Events and Comparative Performance of Comorbidity Indices.Healthcare (Basel, Switzerland) · 2026Article
- Delayed Ischemic Hepatocellular Injury Following Cemented Total Hip Arthroplasty: A Case Report Within the Spectrum of Bone Cement Implantation Syndrome.Life (Basel, Switzerland) · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Frailty, a common syndrome involving multisystem impairment in older adults, is a significant preoperative concern for hip fracture patients. However, its specific link to postoperative complications remains unclear. This systematic review and meta-analysis investigates the association between preoperative frailty and adverse surgical outcomes in this geriatric population. Methods: We comprehensively searched several databases, including China National Knowledge Infrastructure PubMed, Embase, Web of Science, (China National Knowledge Infrastructure, CNKI), Wanfang, VIP and the Cochrane Library from January 1, 2000, to September 2024. We focused on cohort studies that examine how frailty affects prognosis after hip fracture surgery in older adults. Two researchers independently screened literature, extracted data, and assessed the quality of included studies using the Newcastle-Ottawa Scale (NOS). We used Stata 15.0 to perform the meta-analyses. Results: This review included 27 cohort studies, consisting of 19 retrospective and 8 prospective studies, involving a total of 243,264 patients. When compared to non-frail patients, frailty statistically significantly increases the risk of postoperative mortality following hip fracture. Specifically, frailty is associated within-hospital mortality [(relative risk, RR) = 3.20, 95% (confidence interval, CI): 1.93, 5.31], 30-day mortality (RR = 3.91, 95%CI: 1.89, 8.07), and 1-year mortality (RR = 1.50, 95%CI: 1.39, 1.61). Frailty also increases the rate of complications (RR = 2.81, 95%CI: 1.67, 4.74), postoperative delirium (RR = 4.44, 95%CI: 2.34, 8.41), pneumonia (RR = 4.09, 95%CI: 2.39, 7.01), and 30-day readmission (RR = 1.75, 95%CI: 1.56, 1.96). Conclusion: Frailty increases both short-term and long-term mortality following hip fracture surgery in older patients. Additionally, frailty is associated with a higher overall rate of complications, including the 30-day readmission.
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